The Netherlands X-omics Initiative, led by Radboud university medical center, has received 17 million euros from the Netherlands Organisation for Scientific Research (NOW) as part of the National Roadmap for Large-Scale Research Facilities. The X-omics Initiative is one of ten projects awarded by Minister of Education, Culture and Science Ingrid van Engelshoven. A total of 138 million euros has been allocated to facilitate a large-scale research infrastructure in the Netherlands.In recent years we have seen a spectacular growth of research into genomics, proteomics, metabolomics as well as bioinformatics. The awarding of this X-omics Initiative [pronounced ‘cross-omics’] has given an extra quality incentive to the research structure built up in the Netherlands around genomics (Edwin Cuppen, University Medical Center Utrecht), proteomics (Albert Heck, Utrecht University), metabolomics (Thomas Hankemeier, Leiden University) and integration of data (Alain van Gool, Radboud university medical center).
Cells in action
Coordinator Alain van Gool: “Our objective is to increase the technological possibilities of all these -omics techniques to a high extent. Also, the higher level of data integration will allow us to map the dynamics among the various -omics levels. As yet, analyses of genomics, proteomics and metabolomics are often separate approaches, hardly connecting with each other. With the X-omics Initiative we are now able to integrate all available data on all levels and to use these data for complex, dynamic analyses of the way in which cells and tissues function as a system. Our newly acquired knowledge of these molecular building blocks of life will allow us to see the contours of cells and tissues in action.”
Combining and improving -omics techniques will contribute to more knowledge of the fundamentals of health and disease, for example regarding cancer, immunoreactions, unique rare diseases and the effect of genetic variations among the Dutch population. The Initiative will set up demonstration projects on various levels to illustrate the power of the -omics techniques in these fields. Hans Clevers and Rene Bernards will study cells and organoids for drugs to cure cancer and the development of resistance to these drugs. Mihai Netea and Han Brunner (both from Radboud university medical center) will study individual patients to look for individual differences regarding rare diseases, while Cornelia van Duijn (Erasmus University Medical Center) and Cisca Wijmenga (University Medical Center Groningen) will analyze population-based genetic variations among the Dutch population.
National X-omics Infrastructure
Van Gool explicitly states that the X-omics Initiative is a national initiative: “The added value of this initiative lies to a large extent in the cooperation of the top institutes that are already involved in all these -omics parts and data integration. This is the only way to really make a giant leap forward. We have to make this effort together to achieve that, and we commit ourselves to taking the lead in this field worldwide.”
Zie ook: www.x-omics.nl
Roadmap-subsidies: Ruim 27 miljoen euro naar Radboud-onderzoeksfaciliteiten
The National Roadmap for Large-Scale Research Facilities encourages setting up or improving large research facilities, enabling the Netherlands to take up an important position in the international research field.
The objective of the National Roadmap for Large-Scale Research Facilities is to invest in Dutch research facilities with an international reputation or in Dutch involvement in building or adapting international research facilities.
Related news items
Cognitive behavioral therapy effective in MD1 New treatment option for complex disease21 September 2018
Treatment with cognitive behavioral therapy helps patients with myotonic dystrophy type 1 in improving their physical abilities and social participation. This is the result of a survey of more than 250 patients in four European countries.read more
Successful teamwork between Neurology and Human Genetics leads to identification of two new ataxia genes19 September 2018
Thanks to close cooperation between Bart van de Warrenburg (Neurology) and Erik-Jan Kamsteeg (Humans Genetics) two new genes involved in movement disorders were identified. The genes are relevant for autosomal recessive cerebellar ataxia.read more
Rectal cancer staging using MRI with endorectal filling19 September 2018
In the British Journal of Radiology Rutger Stijns and colleagues, showed that using MRI with endorectal filling did not lead to an improved rectal cancer staging and that it has the potential to influence the distance to a key anatomical landmark.read more
Low risk of progression in persistent non-dysplastic Barrett’s esophagus19 September 2018
In Clinical Gastroenterology and Hepatology Peter Siersema and Yonne Peters showed that patients with stable persistence of non-dysplastic Barrett’s esophagus have a low risk of malignant progression and may not benefit from routine endoscopic surveillance.read more