13 April 2018

The Netherlands X-omics Initiative, led by Radboud university medical center, has received 17 million euros from the Netherlands Organisation for Scientific Research (NOW) as part of the National Roadmap for Large-Scale Research Facilities. The X-omics Initiative is one of ten projects awarded by Minister of Education, Culture and Science Ingrid van Engelshoven. A total of 138 million euros has been allocated to facilitate a large-scale research infrastructure in the Netherlands.

In recent years we have seen a spectacular growth of research into genomics, proteomics, metabolomics as well as bioinformatics. The awarding of this X-omics Initiative [pronounced ‘cross-omics’] has given an extra quality incentive to the research structure built up in the Netherlands around genomics (Edwin Cuppen, University Medical Center Utrecht), proteomics (Albert Heck, Utrecht University), metabolomics (Thomas Hankemeier, Leiden University) and integration of data (Alain van Gool, Radboud university medical center).
 
Cells in action
Coordinator Alain van Gool: “Our objective is to increase the technological possibilities of all these -omics techniques to a high extent. Also, the higher level of data integration will allow us to map the dynamics among the various -omics levels. As yet, analyses of genomics, proteomics and metabolomics are often separate approaches, hardly connecting with each other. With the X-omics Initiative we are now able to integrate all available data on all levels and to use these data for complex, dynamic analyses of the way in which cells and tissues function as a system. Our newly acquired knowledge of these molecular building blocks of life will allow us to see the contours of cells and tissues in action.”
 
Demonstration projects
Combining and improving -omics techniques will contribute to more knowledge of the fundamentals of health and disease, for example regarding cancer, immunoreactions, unique rare diseases and the effect of genetic variations among the Dutch population. The Initiative will set up demonstration projects on various levels to illustrate the power of the -omics techniques in these fields. Hans Clevers and Rene Bernards will study cells and organoids for drugs to cure cancer and the development of resistance to these drugs. Mihai Netea and Han Brunner (both from Radboud university medical center) will study individual patients to look for individual differences regarding rare diseases, while Cornelia van Duijn (Erasmus University Medical Center) and Cisca Wijmenga (University Medical Center Groningen) will analyze population-based genetic variations among the Dutch population.
 
National X-omics Infrastructure
Van Gool explicitly states that the X-omics Initiative is a national initiative: “The added value of this initiative lies to a large extent in the cooperation of the top institutes that are already involved in all these -omics parts and data integration. This is the only way to really make a giant leap forward. We have to make this effort together to achieve that, and we commit ourselves to taking the lead in this field worldwide.”
­­­­­­­­­­­­-
Zie ook: www.x-omics.nl
Roadmap-subsidies: Ruim 27 miljoen euro naar Radboud-onderzoeksfaciliteiten
www.nwo.nl/actueel/nieuws/2018/04/nationale-roadmap-138-miljoen-voor-tien-hoogwaardige-onderzoeksfaciliteiten.html
www.nwo.nl/documents/nwo/programmas/gehonoreerde-aanvragen-roadmap-2017-2018
The National Roadmap for Large-Scale Research Facilities encourages setting up or improving large research facilities, enabling the Netherlands to take up an important position in the international research field.
The objective of the National Roadmap for Large-Scale Research Facilities is to invest in Dutch research facilities with an international reputation or in Dutch involvement in building or adapting international research facilities.

Related news items


Bas Loomans received Mid-Career Award

18 July 2019

Bas Loomans received in Vancouver the STEPHEN BAYNE MID-CAREER AWARD of the International Association for Dental Research (IADR)

read more

4,8 million euros for prevention of tuberculosis among people with diabetes in Africa

16 July 2019

Reinout van Crevel and Lindsey te Brake have received European funding of 4.8 million euros to lead an international consortium to screen thousands of people with diabetes in Uganda and Tanzania for TB, and investigate the effect and costs of 3 months preventive treatment for TB.

read more

The real impact of menstrual complaints on work and school productivity

8 July 2019

Menstrual period symptoms may be linked to nearly nine days of lost productivity every year, through presenteeism, suggests the largest study of its kind, published in the journal BMJ Open. But the real impact on women and society is underestimated and poorly appreciated, say the researchers.

read more

Walking for science Research by Radboud university medical center and Radboud University during the Vierdaagse (Four Day Marches)

5 July 2019

The Vierdaagse is a unique opportunity to conduct research into physical activity and healthy lifestyle.

read more

Prostate cancer theranostics imaging, surgical guidance, and targeted photodynamic therapy

5 July 2019

In Theranostics, Mark Rijpkema and colleagues present the development of a novel multimodal tracer that targets both preoperative imaging, surgical guidance, and targeted photodynamic therapy of PSMA-expressing prostate cancer.

read more

Effects of prophylactic haloperidol on long-term quality of life in ICU Patients

4 July 2019

In Anesthesiology, Paul Rood, Marieke Zegers and Mark van den Boogaard described that prophylactic haloperidol use does not affect long-term quality of life in critically ill patients at high risk for delirium.

read more