Gert Jan Veenstra, theme Cancer development and immune defense, and Robert Passier of the University of Twente, received a ZonMw Top grant of € 675,000 for a project entitled: ldentification of molecular regulatory pathways for specification and maturation of human cardiac subtypes. In this project the researchers will collaborate with medical centres in Leiden (LUMC) and Amsterdam (AMC, VUmc).Cardiovascular disease is the leading cause of death in the western world. Ten years ago it became possible to reprogram patient cells (for example cells obtained from skin or blood) to human induced pluripotent stem cells (hPSC). These cells can be differentiated into a range of somatic cell types, including cardiomyocytes. However these cells have a variety of cardiac identities that are more similar to fetal than to adult heart muscle cells. In the project funded by ZonMw the objective is to understand how to direct heart cells to the correct cardiac identity and how to let them mature to adult cardiomyocytes.
For the first time the genetic and molecular mechanisms that are important for differentiation and maturation of cardiomyocyte subtypes will be studied extensively. The project is expected to make an important contribution to the understanding, modeling and treatment of heart disease.
Related news items
Peter-Bram ‘t Hoen appointed as professor of Bioinformatics and head CMBI23 February 2018
The Executive Board has appointed Peter-Bram ‘t Hoen as professor of Bioinformatics with a focus on Personalized Medicine, and head of the Centre for Molecular and Biomolecular Informatics (CMBI) by 1 March 2018.read more
Haloperidol does not prevent delirium or improve survival rates in ICU patients Large-scale study shows commonly used drug has no preventive effect21 February 2018
Prophylactic use of the drug haloperidol does not help to prevent delirium in intensive care patients or improve their chances of survival. Therefore, there is no reason anymore to administer the drug as a preventive measure to reduce the burden of delirium.read more