5 February 2019

Guoqiang Yi and Joost Martens, theme Cancer development and immune defense, published in Cell Reports about chromatin-based classification of genetically heterogeneous AMLs into two distinct subtypes with diverse stemness phenotypes.

Publication in Cell Reports: link.

Global investigation of histone marks in acute myeloid leukemia (AML) remains limited. Analyses of 38 AML samples through integrated transcriptional and chromatin mark analysis exposes 2 major subtypes. One subtype is dominated by patients with NPM1 mutations or MLL-fusion genes, shows activation of the regulatory pathways involving HOX-family genes as targets, and displays high self-renewal capacity and stemness. The second subtype is enriched for RUNX1 or spliceosome mutations, suggesting potential interplay between the 2 aberrations, and mainly depends on IRF family regulators. Cellular consequences in prognosis predict a relatively worse outcome for the first subtype.

Their integrated profiling provides a comprehensive resource for investigating the molecular basis and underpinnings of AML progression in primary samples.

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