29 April 2019

The use of oligonucleotides as therapeutics requires the packaging into nanoparticles. Positively charged peptides are one type of molecules to generate such nano-formulations. To this point, the inner architecture of these nanoparticles and how it depends on the relative amounts of oligonucleotide and peptide could not be resolved.

In a collaborative effort that has just been published in Nano Letters, the group of Lorenzo Albertazzi, TU Eindhoven, together with the group of Roland Brock, theme Nanomedicie, used superresolution microscopy to quantitatively image the structure and composition of peptide – messenger RNA nanoparticles and related this to biological activity. Such insights will be crucial for the development of highly effective nanomedicine.
 

Related news items


Prinses Beatrix Spierfonds grant to investigate patient stratification in myotonic dystrophy

24 January 2020 RIMLS researchers Rick Wansink and Roland Brock, both theme Nanomedicine, received a € 280,000 grant from the Prinses Beatrix Spierfonds. read more

RIMLS PhD grants awarded to eight RIMLS (j)PI's

12 September 2019 Recently, RIMLS held an internal call for Radboudumc junior researcher (PhD) positions. Congratulations for all the awardees and all the best in conducting the research projects. read more

TURBO grants for four medical-technical research projects

8 November 2018 Four TURBO grants were awarded to new technical-medical research proposals. The grants are part of the TURBO program, a collaboration between Radboudumc and the University of Twente. read more

New drug delivery systems published by Wouter Verdurmen

23 October 2017 These results are recently published in Scientific Reports. read more