24 November 2020

An NWO XS project has been granted to the lab of Hendrik Marks, theme Cancer development and immune defence.

During embryonic development in mammals, female cells silence one of the two X chromosomes in a process called X-chromosome inactivation, resulting in one active X chromosome similar to male cells. Although the start of X inactivation is well understood, the proteins responsible for subsequent gene silencing on the future inactive X chromosome are unknown.

We will apply powerful new labelling strategies to identify these proteins. Successful execution of this project will provide exciting new insights into regulation of the genome, and opens up unexplored avenues to investigate how misregulation of X inactivation causes diseases specific to women.

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