People Marije Koenders

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Marije Koenders PhD

+31 (0)24 361 66 19
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Marije Koenders assistant professor

My research team focuses on cytokine targeting and immunomodulation to (selectively) dampen the immune response to suppress synovial inflammation during arthritis and to prevent further destruction of cartilage and bone.

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Marije Koenders assistant professor

My research team focuses on cytokine targeting and immunomodulation to (selectively) dampen the immune response to suppress synovial inflammation during arthritis and to prevent further destruction of cartilage and bone. We approach this by blocking proinflammatory cytokines and by inhibiting the (development of) pathogenic T lymphocytes. Closely related with this T cell research is our research on the effects of modulation of intestinal flora on the development of arthritis, and the activation of several Toll-Like Receptors (TLRs) involved in this. Within the European IMI project "BeTheCure" we contribute to the standardization of murine models of experimental arthritis, and we participate in the research on new therapeutic targets in the IL-17 and TLR pathways. Because of our long-standing expertise in animal models, we also collaborate with external parties in the screening of new therapeutic agents in our RA and OA models. To translate potential new targets from bench to bedside, we make use of the human synovium SCID mouse model, which we extensively validated with frequently applied biological treatments. Combining our in vitro assays, classical in vivo systems and this translational model of RA, we contribute to the preclinical research and development of new, personalized treatment in rheumatic diseases.

Personal prizes & awards national & international

  • 2015: Koenders’ paper “Novel therapeutic targets in rheumatoid arthritis” (TIPS 2015) was rated “highly-cited article”
  • 2008: 2010 & 2013: EULAR Travel Bursary
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Personal prizes & awards national & international

  • 2015: Koenders’ paper “Novel therapeutic targets in rheumatoid arthritis” (TIPS 2015) was rated “highly-cited article” by Web of Science (Thomson Reuters) as of May/June 2016 (top 1% of its academic field based on a highly cited threshold for the field and publication year)
  • 2008: 2010 & 2013: EULAR Travel Bursary
  • 2008: Young Investigator Award (EULAR)
  • 2005: NCMLS Award for Best Oral Presentation (NCMLS PhD conference)
  • 2005: EWRR Postgraduate Fellowship
  • 2004: EULAR Abstract Award
  • 2004: EULAR Award for An outstanding presentation of the abstract (EWRR)
  • 2003: NCMLS Award for Best Poster Presentation (NCMLS PhD conference 2003)

Additional functions

  • Member of the BeTheCure study group for standardization of animal models
  • Associate Faculty Member of the F1000
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Additional functions

  • Member of the BeTheCure study group for standardization of animal models
  • Associate Faculty Member of the F1000
  • Member of the Editorial Board of Scientifica, Hindawi Publishing Corporation
  • Member of the Editorial Board of Autoimmune Diseases & Therapeutic Approaches, Aperito Publications
  • Member of the Editorial Board of “Mediators of Inflammation”

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Field of study

Rheumatology

Radboud Institute for Molecular Life Sciences

Our main aim is to achieve a greater understanding of the molecular mechanisms of disease. By integrating fundamental and clinical research, we obtain multifaceted knowledge of (patho)physiological processes. read more