People Nicole van de Kar

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Nicole van de Kar MD PhD

+31 (0)24 361 44 30
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Nicole van de Kar medical specialist

Nicole van de Kar is a pediatric nephrologist and staff member of the department of pediatric nephrology at the Radboudumc.

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Nicole van de Kar medical specialist

Nicole van de Kar is a pediatric nephrologist and staff member of the department of pediatric nephrology at the Radboudumc. She obtained her  PhD in 1994 (cum laude) with a thesis on the pathophysiology of the hemolytic uremic syndrome caused by shiga-toxin producing E.coli infections.  She currently coordinates several research projects , in particular optimalizing the eculizumab treatment in aHUS and research on basic mechanisms, assay development and  diagnostic toolbox for complement mediated disorders (COMBAT).

Her current interests include the pathophysiology of the hemolytic uremic syndromes in particular the hemolytic uremic syndrome (HUS) caused by shiga toxin producing E.coli (STEC) infections and the atypical HUS caused by dysregulation of the complement system as well as the complement mediated renal disorders C3 glomerulopathy. The laboratory she works for, performs the clinic-immunological and genetic diagnostics for HUS and C3G in  the  Netherlands. 

Additional functions

  • Member of the International Pediatric Nephrologist HUS working group
  • Member and chair of the international Steering Committee on Shiga toxin producing E.coli
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Additional functions

  • Member of the International Pediatric Nephrologist HUS working group
  • Member and chair of the international Steering Committee on Shiga toxin producing E.coli
  • Chair of the Dutch HUS working group HUS in which all university centers participate

Field of study

Paediatrics

Radboud Institute for Molecular Life Sciences

Our main aim is to achieve a greater understanding of the molecular mechanisms of disease. By integrating fundamental and clinical research, we obtain multifaceted knowledge of (patho)physiological processes. read more