Preclinical sarcoma research
The ultimate aim of my research is to design an optimal treatment strategy for sarcoma patients. This is done by rationally positioning and incorporating the novel concept of targeted therapy and/or immunotherapy with molecular imaging in current treatment strategies to enable individualization of therapy and consequently protect patients against the toxic effects of ineffective treatment. In tumor material, linked to clinical outcome, we search for prognostic and predictive markers for therapy. In vitro, tumor cell lines are used to study the effect of different treatments. These results are validated in vivo in sarcoma xenograft models developed for this work. Molecular imaging techniques are used to monitor or predict the therapeutic effect in vivo.