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Agenda General
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This minisymposium focuses on the latest developments on imaging modalities to visualize biological processes from molecules to complete organisms. It is organized in the context of the bachelor minors “Cancer mechanisms and immune defense (MIN04)” and “Visualizing Health and Disease (MIN02)” and the invited speakers are Lukas Kapitein (Utrecht University), Colinda Scheele (VIB-KU Leuven), Sanne van Lith and Sandra Heskamp (both Radboudumc).
13:30 - 14:10 Lukas Kapitein (Utrecht University)
Mapping cellular organization using Expansion Microscopy.
Recently, a new form of super-resolution microscopy was introduced that is based on fourfold physical expansion of the sample of interest. In my presentation, I will show how we have used this to quantitatively map cytoskeletal organization in neurons. In addition, I will show how we have recently succeeded in establishing Tenfold Robust Expansion Microscopy (T-REx), which enables three-dimensional mapping of cellular organization in complex tissue, such as the airway epithelium.
14:10 - 14:50 Colinda Scheele (VIB-KU Leuven)
Multi-dimensional imaging of stem cell dynamics and tumor initiation in the breast.
How does the healthy tissue architecture influence the different steps of tumorigenesis? To study this question, we use and develop advanced imaging approaches, which enable us to visualize the highly dynamic process of tumorigenesis in a multi-dimensional way. In my talk I will focus on how the mammary gland is organized, and how this organization provides several layers of protection against tumor formation.
14.50 - 15.10 Break
15:10 - 15:50 Sanne van Lith (Radboudumc, Nijmegen)
Tumors in the spotlight: multimodal imaging and photodynamic therapy in cancer treatment.
At the department of Medical Imaging, we are developing tumor-targeting compounds that are dual-labeled with a chelator and a photosensitizer for implementation in nuclear imaging, radioguidance, optical imaging and photodynamic therapy. In this seminar, an outlook will be given on how these compounds and techniques can be applied in treatment of various cancer types.
15:50 - 16:30 Sandra Heskamp (Radboudumc, Nijmegen)
Nuclear imaging in immuno-oncology.
Currently, numerous immuno-oncological drugs are being developed to treat cancer patients. However, many questions remain unanswered, such as how, when, and for whom this treatment is most effective. This lecture will address the potential role of nuclear imaging in immunotherapy drug development and to improve personalized therapy.
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