Researchers at Radboudumc have found indications in a small-scale study that tocolytics can reduce menstrual pain in women with endometriosis. If follow‑up research confirms these results, it could pave the way for a new treatment option. The study has already received attention from Dutch media outlets, including NOS.
In endometriosis, tissue resembling the lining of the uterus grows outside the uterus, for example on the ovaries, bladder, or intestines. This can lead to severe menstrual pain, as well as chronic abdominal complaints, fatigue, pain during intercourse, or problems with urination and bowel movements. Endometriosis can also reduce fertility. It is estimated that about one in ten women are affected.
Pain reduction
In the study, a small group of women with endometriosis received an intravenous infusion of tocolytics for six hours on the day their menstrual pain was at its peak. These drugs are normally used to delay preterm labor. Gynecologist Bertho Nieuwboer explains: ‘The results are positive. The women reported experiencing less pain on the same day, without the need for additional painkillers. The pain reduction also seemed noticeable during the rest of their menstrual cycle.’
Follow-up research
This is an initial study designed to assess whether tocolytics have any effect at all on menstrual pain caused by endometriosis. Further research in a larger group of women is needed to confirm these findings. Whether tocolytics will ultimately be used as a new treatment depends on the outcomes of these larger studies.
Current treatment options
Radboudumc has extensive expertise in the field of endometriosis and already offers several treatment options. Would you like to learn more about endometriosis or the available treatments? Visit our website (in Dutch).
If you suspect you have endometriosis, discuss it with your general practitioner. They can refer you to a specialist.
About the publication
This research has been published in Fertility and Sterility: Atosiban as a potential treatment for endometriosis-related pain: results from the ENDOBAN pilot study. Mark Schoep, Elise Taken, Annemiek Nap, Bertho Nieboer. DOI: 10.1016/j.fertnstert.2025.12.019
NOS featured this study on Sunday, 8 February, in the 8 o’clock news broadcast. You can rewatch the broadcast here or read the related news article via this link (in Dutch).
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