22 May 2020

Since 1990, the Osteoarthritis Research Society International (OARSI) has awared the Basic Science Award annually. Purpose of this prize is to stimulate fundamental research in the field of osteoarthritis. This year Peter van der Kraan, Dept. of Experimental Rheumatology, theme Inflammatory diseases, has won this award for his work in understanding the role of the growth factor Transforming Growth Factor beta (TGF-beta) in healthy cartilage and in osteoarthritis.

Peter van der Kraan and collaborators were the first to demonstrate that TGF-beta drives the formation of osteophytes and synovial fibrosis in OA joints, 2) found that TGF-beta acts as a protective, load-stimulated factor in a healthy, young joint, but as a harmful factor in an arthrotic joint, 3) that the protective function of TGF-beta decreases in old cartilage compared to young cartilage.

The Basic Science Award was to be presented at the annual osteoarthritis conference that would take place this year in Vienna. The official ceremony has been postponed by Corona. Of course, winning this prize is not a merit of Peter van der Kraan only, but an achievement of the entire Experimental Rheumatology laboratory, in addition to several PhD candidates and post-docs, in particular Henk van Beuningen, Esmeralda Blaney Davidson and Arjan van Caam.
 

Related news items


BCG vaccine is safe with no increased risk of COVID-19 symptoms says Mihai Netea

11 August 2020

The BCG vaccine has a general stimulatory effect on the immune system and is therefore effective against multiple infectious diseases - possibly also against COVID-19.

read more

650,000 Euro funding for research into the phasing out of medication for leukaemia patients

30 July 2020

With a 650,000 euro funding from ZonMw, researchers from the Haematology and Pharmacy departments can develop a medication phasing out strategy for patients with chronic myeloid leukaemia. This strategy will be tested in practice.

read more

Increased role of patients after bowel cancer treatment

30 July 2020

Approximately 14,000 patients get colorectal cancer every year. Almost all patients are operated on and monitored afterwards (follow-up). In 2019 Radboudumc started a new approach to follow-up research after the treatment of stage II/III colorectal cancer.

read more

ERC Proof of Concept grant received by Ronald van Rij

30 July 2020

Ronald van Rij, theme Infectious diseases and global health, received an ERC (European Research Council) Proof of Concept grant of 150,000 euros, in order to make arbovirus vaccines even safer.

read more

Hypatia fellowship Call is open

30 July 2020

The Hypatia fellowship round with the deadline 31 May has been canceled. Therefore, the next available deadline will be 27 September 2020. Radboudumc researchers are invited to scout young potentials to fill the strategic gaps within the research themes imbedded in RIHS and RIMLS.  

read more

Mihai Netea and colleagues published two papers back-to-back in The Journal of Clinical Investigation. 

29 July 2020

These back-to-back articles investigated the effect of BCG vaccination on trained immunity. The first article shows that BCG vaccination inhibits systemic inflammation, depending on gender. The second article demonstrates that the circadian rhythm influences the induction of trained immunity.

read more