The Board of NWO Domain Science has awarded in the NWO Open Competition Domain Science, Ronald van Rij, theme Infectious diseases and global health and Jennny van der Wijst, theme Renal disorders, an XS grant. The maximum funding is 50.000 euros per project. The XS category emphatically strives to encourage curiosity-driven and bold research involving a relatively quick analysis of a promising idea. As a pilot, applicants are also an assessor in the XS assessment process.
Ronald van Rij
Project: Defining the regulatory circuit that drives early development of virus-transmitting mosquitoes
Complex organisms are composed of a wide diversity of cell types, tissues, and organs, yet they all emerged from just a single fertilized cell. The very first steps in this developmental process are similar between different animal species, however, they can differ greatly at the molecular level. Early embryonic development has not been studied in the mosquito Aedes aegypti that is responsible for transmission of important epidemic viruses. In this project, the researchers will unravel genes that are essential for early development of this important mosquito species.
Project: Novel peptide therapeutic to fight kidney stones
Kidney stones affect around 1 in 10 people worldwide. It can be treated, but recurrence rates are high (>30%) resulting in increased risk of chronic kidney disease. An improved, possibly preventive treatment is needed. Our research aims to develop a novel drug to prevent kidney stone formation, based on our body’s calcium regulation. Calcium, obtained from our diet and essential for i.a. bone, can precipitate in our kidneys. This may lead to crystal formation, and ultimately kidney stone development. We propose to stop this process and prevent stone formation by local calcium buffering in the kidney via an original peptide-drug.
Related news items
BCG vaccine is safe with no increased risk of COVID-19 symptoms says Mihai Netea11 August 2020
The BCG vaccine has a general stimulatory effect on the immune system and is therefore effective against multiple infectious diseases - possibly also against COVID-19.read more
650,000 Euro funding for research into the phasing out of medication for leukaemia patients30 July 2020
With a 650,000 euro funding from ZonMw, researchers from the Haematology and Pharmacy departments can develop a medication phasing out strategy for patients with chronic myeloid leukaemia. This strategy will be tested in practice.read more
Increased role of patients after bowel cancer treatment30 July 2020
Approximately 14,000 patients get colorectal cancer every year. Almost all patients are operated on and monitored afterwards (follow-up). In 2019 Radboudumc started a new approach to follow-up research after the treatment of stage II/III colorectal cancer.read more
ERC Proof of Concept grant received by Ronald van Rij30 July 2020
Ronald van Rij, theme Infectious diseases and global health, received an ERC (European Research Council) Proof of Concept grant of 150,000 euros, in order to make arbovirus vaccines even safer.read more
Testing medical mouth masks Developed in the Netherlands30 July 2020
Auping and AFPRO developed medical mouth caps which were tested by Integrative Physiology. The results were shared with the producing companies.read more