Research is focused along two research themes: (1) development and characterization of novel implant surfaces; this research aims at the development of metal, ceramics or ceramics-coated metal implants with enhanced biomineralization properties. The latter is achieved e.g. by the implementation of well-controlled nano-scale topography on the surface of the implant, using a number of different nanotechnological methods, and (2) construction of synthetic bone substitutes; bone is the most commonly replaced tissue, second only to blood. In the research, emphasis is put on the development of instructive materials and synthetic scaffolds for bone regeneration as promising alternatives to overcome the problems associated with routine therapeutic applications (i.e. autografts and allografts).