René Bindels PhD


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René Bindels PhD
+31 (0)24 361 42 11
scientific director of RIMLS

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René Bindels full professor

  • Appointed full professor and head of department in 2003
  • Scientific director of the Radboud Institute for Molecular Life Sciences, since 2010
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René Bindels full professor

René Bindels is as physiologist interested in the regulation of ion transport processes in kidney and small intestine in health and disease.

Current projects involve the molecular mechanisms controlling the calcium and magnesium balance in general and the regulation of the new family of epithelial calcium and magnesium channels (TRPV5, TRPV6, TRPM6 and TRPM7) in particular.

In addition, the functional consequences of mutations in the human ROMK2, NKCC2, NCC and TRPM6 transporters identified in Bartter and Gitelman syndrome and inherited hypomagnesemia are investigated. The studies include use of established epithelial cell lines, tissue-specific knockout mice models, and electrophysiological and biochemical analysis of channel activity.

He is responsible for several physiology courses for medical and health science students. He is an elected member of the Academia Europaea. Since 2010 he is the scientific director of the Radboud Institute for Molecular Life Sciences (RIMLS).

Research group Understanding tubulopathies

René Bindel's research group studies the regulation of ion transport processes in kidney and small intestine in health and disease. Current projects involve the molecular mechanisms underlying rare tubulopathies and the regulation of the newly identified calcium, magnesium and sodium transporters.

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Personal prizes & awards national & international

  • Elected member of the Academia Europaea
  • Carl W. Gottschalk Distinguished Lecturer of the American Physiological Society Renal Section
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Personal prizes & awards national & international

  • Elected member of the Academia Europaea
  • Carl W. Gottschalk Distinguished Lecturer of the American Physiological Society Renal Section
  • Robert Franklin Pitts Lecturer from the International Union of Physiological Sciences (IUPS)
  • Homer W. Smith award from the American Society of Nephrology
  • Knight of the Order of the Dutch Lion

Additional functions

  • Chair of the Secretion and Absorption Commission of the International Union of Physiological Sciences
  • Executive editor of Pflügers Archiv - European Journal of Physiology (2007-2016)
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Additional functions

  • Chair of the Secretion and Absorption Commission of the International Union of Physiological Sciences
  • Executive editor  of Pflügers Archiv - European Journal of Physiology (2007-2016)
  • Chair of Radboudumc' s UMC-Raad (2008-2010)
  • Member of the organizing committee of the Kidney Week of the American Society of Nephrology (2013)
  • Member of various scientific associations: Nederlandse Vereniging voor Fysiologie, Nederlandse Federatie voor Nefrologie, American Society of Nephrology, International Society of Nephrology, American Physiological Society
  • Member of the  editorial board of various scientific magazines: Journal of the American Society of Nephrology, Kidney International, American Journal of Physiology, Renal Physiology, Acta Physiological

Education

  • 1968-1974: High school (Canisius College, Nijmegen)
  • 1974-1981: University (Biology, Katholieke Universiteit Nijmegen)
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Education

  • 1968-1974: High school (Canisius College, Nijmegen)
  • 1974-1981: University (Biology, Katholieke Universiteit Nijmegen)
  • 1986: PhD (Katholieke Universiteit Nijmegen) Promotor: prof. dr. J. Slegers Titel thesis: Phosphate, calcium and magnesium metabolism in the spontaneously hypertensive rat

Field of study

Physiology


Radboud Institute for Molecular Life Sciences

Our main aim is to achieve a greater understanding of the molecular mechanisms of disease. By integrating fundamental and clinical research, we obtain multifaceted knowledge of (patho)physiological processes.

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