People Rick Greupink

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dr. Rick Greupink

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About Rick Greupink

Rick Greupink's work aims to better understand the pharmacological mechanisms that determine drug disposition and toxicity, in order to improve drug safety and personalized pharmacotherapy.

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About Rick Greupink

Dr. Rick Greupink obtained a MSc in pharmaceutical sciences and was trained as a pharmacist (PharmD) at the University of Groningen. He obtained a PhD in Pharmacokinetics and Drug Delivery from the same university and further specialized as a pharmacologist during postdoctoral fellowships in both clinical as well as pre-clinical settings in pharmaceutical industry and academia. He is a registered pharmacologist with the Dutch Pharmacological Society and serves on the board of the Society. He lectures in pharmacology and pharmacotherapy at Radboud University Medical Center, Radboud University and the Arnhem-Nijmegen University of Applied Sciences. At Radboud University Medical Center, Rick holds the status of associate Principle Lecturer and he is a member of the Program Committee for the Biomedical Sciences curriculum (Opleidingscommissie-BMW).

Rick is an Assistant Professor and staff member of the Department of Pharmacology and Toxicology. His research focuses on translational and predictive pharmacology, in particular the in vitro-to-in vivo extrapolation (IVIVE) of drug disposition and drug-induced toxicity. By combining in vitro pharmacology studies in human tissues and cells with in silico modeling, he aims to develop a better understanding of how drugs behave in the body, predict clinical pharmacokinetics and anticipate therapeutic and off-target effects. Next to improving our understanding of the pharmacological mechanisms driving clinical effects, the approach also aids in guiding drug and dose selection in special patient populations and allows pharmacological characterization of molecules still in the early phases of drug discovery.

In his work, Rick combines in vitro laboratory studies with physiology-based pharmacokinetic (PBPK) modeling to predict systemic and tissue exposure, as well as pharmacophore modeling approaches to study and predict target binding. Within this field, he has a special interest in the pharmacological roles of drug-transporting membrane proteins and the outlined approach is used to address absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) questions involving barrier and excretory tissues such as liver, kidney and gut.

Current projects center around the placental disposition and effects of small and large molecule pharmaceuticals during pregnancy, in relation to maternal, fetal and perinatal pharmacokinetics and drug safety.


Positions

  • assistant professor FarmTox

Additional Functions

  • Secretary General & Treasurer of the Dutch Pharmacological Society
  • Member of the Program Committee for Biomedical Sciences (Opleidingscommissie-BMW Radboudumc)
  • Member of the Education Committee of the Dutch Pharmacological Society
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Additional Functions

  • Secretary General & Treasurer of the Dutch Pharmacological Society
  • Member of the Program Committee for Biomedical Sciences (Opleidingscommissie-BMW Radboudumc)
  • Member of the Education Committee of the Dutch Pharmacological Society
  • Module Coordinator 3MFK- Pharmacokinetics (undergraduate program medicine / biomedical sciences)
  • Module Coordinator 3MFD - Pharmacodynamics (undergraduate program medicine / biomedical sciences)
  • Course Coordinator KFARM2 - Molecular Pharmacology in Drug Design (elective course, undergraduate program medicine / biomedical sciences)
  • Course Coordinator BMS63 - Biodynamic and Toxicokinetic Modeling (graduate program biomedical sciences, drug safety and toxicology specialization)

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Research position

  • assistant professor