Freezing of gait, an absence of forward progression of the feet despite the intention to walk, is a debilitating symptom of Parkinson's disease. Laser shoes that project a line on the floor to the rhythm of the footsteps help trigger the person to walk. The shoes benefit the wearer significantly, according to research by the University of Twente and Radboud university medical center, which will be published on December 20 in Neurology, the scientific journal of the American Academy of Neurology.Walking problems are common and very disabling in Parkinson’s disease. In particular, freezing of gait is a severe symptom which generally develops in more advanced stages. It can last seconds to minutes and is generally triggered by the stress of an unfamiliar environment or when medication wears off. Because the foot remains glued to the floor but the upper body continues moving forward, it can cause the person to lose her balance and fall.
Lines on the floor
Parkinson patient experience a unique phenomenon. By consciously looking at objects on the floor, such as the lines from a zebra crossing (‘visual cues’), and stepping over them, they are able to overcome their blockages during walking. This activates other circuits in the brain, hereby releasing the blockages and allowing the person to continue walking. This is why patients often make use of floor tiles at home. With the laser shoes, these useful cues can be continuously applied in everyday life, to walk better and safer. The principle behind the laser shoes is simple: upon foot contact, the left shoe projects a line on the floor in front of the right foot. The patient steps over or towards the line, which activates the laser on the right shoe, and so on.
The present research study shows a beneficial effect in a large group of patients. The number of 'freezing' episodes was reduced by 46% with the use of the shoes. The duration of these episodes was also divided by two. Both effects were strongest in patients while they had not taken their medication yet. This is typically when patients experience the most problems with walking. But an improvement was also seen after the patients had been taking their medication.
"Our tests were administered in a controlled lab setting with and without medication," says researcher Murielle Ferraye. " Further research in their everyday environment is necessary. We plan on testing this using laser shoes that in the meantime came on the market."
Activating the laser
Of the nineteen patients who tested the shoes, the majority would be happy to use them. The patients did not seem to mind that the laser was activated for each single step. "Ideally, the laser should only be activated once the blockage is detected, but we're not quite there yet," says Ferraye. "Freezing is a very complex phenomenon."
Murielle Ferraye, who developed the laser shoes, conducted her study at the Donders Institute at Radboud university medical center and the MIRA Institute for Biomedical Technology and Technological Medicine at the University of Twente.
Related news items
Adjunct Professorship awarded to Barbara Franke at the Goethe University in Frankfurt am Main21 January 2019
Barbara Franke is awarded an honorary Adjunct Professorship at the Goethe University in Frankfurt am Main in Germany.read more
Ignacio Malagon, first professor of Pediatric Anaesthesiology in the Netherlands21 January 2019
Ignacio Malagon has been appointed professor of Pediatric Anaesthesiology at Radboud University / Radboud university medical center with effect from 1 January 2019. He is the first professor in this field in the Netherlands.read more
Two papers on molecular mechanisms of GFI1B in inherited bleeding syndromes in Haematologica21 January 2019
Rinske van Oorschot from the Van der Reijden group, theme Cancer development and immune defense, has published two papers on the transcription factor GFI1B in Haematologica.read more
Blog: Species Differences The Elephant in the Room17 January 2019
Read the blog of Merel Ritskes-Hoitinga in the New England anti-vivisection society (neavs) based on a paper published in the Journal of Translational Medicine.read more
Bart-Jan Kullberg nominated for ZonMw Medical Inspirator Award17 January 2019
This prize is awarded for the most inspiring collaboration between patients and medical researchers. You can vote till 11 February.read more