13 January 2017
These mosquitoes carry high levels of virus without apparent fitness loss, and it is thought that the immune system of the mosquito controls virus replication to non-pathological levels. Insect immunity relies on the recognition of viral RNA and its degradation into small interfering RNAs (siRNAs).
The group recently found that viral RNA is also processed into another class of small RNAs, PIWI-interacting RNAs (piRNAs). In this review, the authors provide an overview of the biogenesis and functions of this enigmatic class of small RNAs.
They published their findings in PLoS Pathogens.
In a recent article in PLoS Pathogens, Pascal Miesen, Joep Joosten, and Ronald van Rij, theme Infectious diseases and global health provide an overview of a novel class of viral RNAs - PIWI-interacting RNAs - in vector mosquitoes.
Arthropod-borne viruses (arboviruses) such as Dengue, Zika, and Chikungunya virus are transmitted by the mosquito Aedes aegypti.These mosquitoes carry high levels of virus without apparent fitness loss, and it is thought that the immune system of the mosquito controls virus replication to non-pathological levels. Insect immunity relies on the recognition of viral RNA and its degradation into small interfering RNAs (siRNAs).
The group recently found that viral RNA is also processed into another class of small RNAs, PIWI-interacting RNAs (piRNAs). In this review, the authors provide an overview of the biogenesis and functions of this enigmatic class of small RNAs.
They published their findings in PLoS Pathogens.
Related news items
Grants for research on magnesium deficiency and malaria Vidis for Felix Hol and Jeroen de Baaij
1 July 2022 Radboudumc researchers Jeroen de Baaij and Felix Hol both receive an NWO Vidi grant for their research, respectively on magnesium deficiency in type 2 diabetes and on malaria. read moreField research on malaria vaccine offers unexpected surprise
23 May 2022Field research on the effectiveness of a malaria vaccine, came up with unexpected results for an international group of researchers including Benjamin Mordmüller of Radboudumc. The vaccine evokes a broader response against malaria proteins than there are in the vaccine.
read more