18 December 2018

On 7 December, Marlène Hekman, theme Urological cancers, has defended her PhD thesis entitled “Tumor-targeted imaging of cancer with radiolabeled and fluorescently labeled antibodies”.

Based on her excellent thesis and performance during the defense, the doctorate was awarded with the distinction 'cum laude'.

The aim of the studies described in this thesis was the clinical translation of targeted imaging using radiolabeled and fluorescently labeled antibodies. By conjugating a radionuclide or a fluorescent molecule to an antibody, a tumor-targeting imaging tracer is created that can be used to visualize tumors. The preclinical studies have shown the additional value of dual-modality imaging in the detection of small tumors in models for colorectal and ovarian cancer. Next, two clinical applications of targeted imaging with girentuximab in clear cell renal cell carcinoma (ccRCC) were described; as a diagnostic tool for ccRCC (89Zr-girentuximab) and for intraoperative guidance of ccRCC resection (111In-girentuximab-IRDye800CW).This thesis shows that sensitive non-invasive or intraoperative imaging techniques can improve the management of patients with cancer. Ultimately, the combination of several intraoperative techniques may deliver the best information to lead patient management in a personalized fashion.

Read more

Related news items

1.5 million for research into young people with mild intellectual disabilities

13 November 2019

Researchers from the Radboud University and Radboudumc will partner with social organisations to map how often young people with mild intellectual disabilities have psychological problems and how they can be treated. The project was recently awarded a subsidy of 1.5 million euro by ZonMw.

read more

Bart van de Warrenburg appointed visiting professor at the UKM Medical Centre in Kuala Lumpur

11 November 2019

Neurologist and Principal Investigator at the Donders Institute Bart van de Warrenburg has been appointed visiting professor at the UKM Medical Centre in Kuala Lumpur.

read more

KNAW Van Leersum beurs for Mohammad Alsady

7 November 2019

Mohammad Alsady, theme Disorders of movement, received the “KNAW Van Leersum beurs”.

read more

3D breast ultrasound elastography to improve breast cancer detection

5 November 2019

One out of seven women will be diagnosed with breast cancer during their life. Early detection of breast cancer is important to increase the survival rate. Gijs Hendriks graduated recently on a new technique, 3D elastography, to detect breast cancer better.

read more

Self-management rehabilitation program improves participation in patients with neuromuscular disease

4 November 2019

Yvonne Veenhuizen, Alexander Geurts theme Neurorehabilitation, Baziel van Engelen, theme Disorders of movement, and colleagues, showed that Energetic improves participation in patients with neuromuscular disease. They have published their results in Neurology.

read more

New NFU eBROK® course open for registration

1 November 2019

This platform is not only for researchers who want to obtain their BROK® certificate, but also for researchers who already have a BROK® certificate and want to keep their certification (re-certification).

read more