18 December 2018

On 7 December, Marlène Hekman, theme Urological cancers, has defended her PhD thesis entitled “Tumor-targeted imaging of cancer with radiolabeled and fluorescently labeled antibodies”.

Based on her excellent thesis and performance during the defense, the doctorate was awarded with the distinction 'cum laude'.

The aim of the studies described in this thesis was the clinical translation of targeted imaging using radiolabeled and fluorescently labeled antibodies. By conjugating a radionuclide or a fluorescent molecule to an antibody, a tumor-targeting imaging tracer is created that can be used to visualize tumors. The preclinical studies have shown the additional value of dual-modality imaging in the detection of small tumors in models for colorectal and ovarian cancer. Next, two clinical applications of targeted imaging with girentuximab in clear cell renal cell carcinoma (ccRCC) were described; as a diagnostic tool for ccRCC (89Zr-girentuximab) and for intraoperative guidance of ccRCC resection (111In-girentuximab-IRDye800CW).This thesis shows that sensitive non-invasive or intraoperative imaging techniques can improve the management of patients with cancer. Ultimately, the combination of several intraoperative techniques may deliver the best information to lead patient management in a personalized fashion.

Read more

Related news items

A "QR code" to read metabolism inside prostate cells: labeled extra-cellular citrate

12 April 2022 In a recent publication in the Proceedings of the National Academy of Sciences USA, Frits van Heijster and his colleagues describe investigations to uncover which carbon sources and metabolic pathways are used by epithelial cells of the prostate to sustain high luminal citrate levels. read more

Vote for the RIMLS Supervisor of the year

7 December 2021

This is your chance to vote for your favourite candidate for supervisor of the year! Support and promote your ideal supervisor from the three nominees: Siroon Bekkering, Gerald Verhaegh and Jo Zhou. Please submit your vote the 20th of December 2021 at the latest.

read more

RIMLS awards call for nominations

19 October 2021 RIMLS awards several prizes to stimulate and honor our (young) researchers. Upcoming awards are Supervisor of the Year, Best Master Thesis, Best Publication, Best Image and more. Send your nominations now before 24 November 2021. read more

Turbo Grants for four medical-technical research projects

19 October 2021 Four TURBO grants were recently awarded to new technical-medical research proposals. The grants are part of the TURBO program, a collaboration between the University of Twente (TechMed Centre) and the Radboudumc. read more

Research into treatment for bladder pain syndrome will now be reimbursed

4 August 2021 Bladder pain syndrome, also called interstitial cystitis, is a chronic benign condition of the urinary bladder read more

RIMLS online award ceremony proudly presenting the winners

13 January 2021 In this special webinar of the RIMLS New Year Celebration, scientific director René Bindels reviewed 2020 and looked forward to 2021. But more importantly a number of researchers received prizes in the traditional RIMLS awards ceremony.  read more