Recently Lily Boutens, Rinke Stienstra and colleagues, theme Vascular damage have published an article in the journal Diabetologia.Publication: Link.
Obesity promotes adipose tissue inflammation contributing to the development of insulin resistance. It has been well established that macrophages accumulate in adipose tissue and drive obesity-induced inflammation. Recent insides from the field of Immunology have revealed that rewiring of macrophage metabolism determines their inflammatory trait. Our results are the first to demonstrate that the enhanced inflammatory trait of adipose tissue macrophages in obesity is accompanied by unique changes in energy metabolism. Specific targeting of macrophage metabolism may represent a therapeutic strategy to actually lower obesity-induced inflammation.
More about: Rinke Stienstra
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