In a recent review in the Journal of Controlled Release (5y IF 8), René Raavé (photo), Toin van Kuppevelt & Willeke Daamen, theme Reconstructive and regenerative medicine, discussed an alternative targeting strategy aimed at delivery of anti-tumor drugs to the tumoral extracellular matrix instead of tumor cells.This targeting strategy has potential to not only eliminate the tumor cells, but also tumor supportive cell types such as cancer associated fibroblasts, cancer associated macrophages and tumor stem cells.
Graphical abstract of the review.
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