28 June 2018

Recently (May 2018) a study in Botswana reported an increased incidence (0.9%) of neural tube defects (NTDs) amongst infants born to women who received dolutegravir (DTG) at conception or early in the first trimester, compared to 0.1% NTDs observed with other antiretrovirals.

Based on these findings the EMA, FDA and WHO issued a safety alert on the use of dolutegravir during conception, and advise not to prescribe dolutegravir for women of child bearing potential who are trying to become pregnant. This underlines the importance of prospective studies in pregnancy.
 
In Clinical Pharmacokinetics David Burger, Angela Colbers, Rob ter Heine en Ruben van der Galiën discuss that although yearly over a million of women with HIV get pregnant, it is often still unknown whether treatment with HIV-integrase inhibitors results in adequate drug exposure. The major mechanisms between altered exposure, the clinical implication and the remaining knowledge gaps are discussed.

publication
Pharmacokinetics of HIV-Integrase Inhibitors During Pregnancy: Mechanisms, Clinical Implications and Knowledge Gaps.
van der Galiën R, Ter Heine R, Greupink R, Schalkwijk SJ, van Herwaarden AE, Colbers A, Burger DM.

David Burger, Angela Colbers and Rob ter Heine are members of theme Infectious diseases and global health.

Related news items


Dutch Brain Foundation grant for EENnacoma

20 February 2020

Lavrijsen and Van Erp: ‘This grant will facilitate practice-based research, professionalization and further academization of EENnacoma, and links between different health care and research institutions all for the benefit of people with prolonged disorders of consciousness and their families.'

read more

RIHS Awards Ceremony five winners

19 February 2020

On 18 February the RIHS 'Koek & Zopie' event took place. In front of an audience of more than 125 colleagues, RIHS awardees accepted their awards for the best PhD thesis, the research product with the highest impact on society, the best peer-reviewed publication and the Supervisor of the year 2019.

read more

Lowlands Science call for projects

17 February 2020

Researchers pay attention! Lowlands is looking for research teams to participate in Lowlands Science 2020. It’s a great way to reach a large audience, do unique experiments with and on them, and to have a memorable experience with your colleagues.

read more

Health Valley 10 - 11 - 12 March

13 February 2020

For three days, professionals from healthcare, health innovation, business, education and science will come together to share their knowledge and experiences about the healthcare of the future.

read more

KNAW Early Career Award for Geert Litjens

13 February 2020

Twelve young researchers received the Early Career Award from KNAW on 4 february. One of them is RIHS researcher Geert Litjens. The Award is aimed at researchers in the Netherlands at the start of their career who are capable of developing innovative and original research ideas.

read more

Interactive career day for Postdocs and PhD candidates

13 February 2020

45 Postdocs and PhD candidates attended the first Interactive career day organised by Janssen Pharmaceutica, to learn more about career perspectives and R&D activities that on the longer term can lead to ideas and potential future collaboration. 

read more