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12 October 2018
The researchers, including Peter Friedl and Eleonora Dondossola, the University of Texas MD Anderson Cancer Center, Houston, had been working to develop a better method for studying bone metastases in animal models of cancer for the last six years. A fluorescent imaging technique called intravital multiphoton microscopy (iMPM) has been used extensively to visualize cancer in soft tissues. However, in order to study bone metastases, the researchers had to figure out a way to enable iMPM to look inside much harder material.
In this 3D cross-section, you see the nuclei (green) and cytoplasm (red) of human prostate cancer cells growing inside a bioengineered construct of mouse bone (blue-green) that’s been placed in a mouse.
The researchers, including Peter Friedl and Eleonora Dondossola, the University of Texas MD Anderson Cancer Center, Houston, had been working to develop a better method for studying bone metastases in animal models of cancer for the last six years. A fluorescent imaging technique called intravital multiphoton microscopy (iMPM) has been used extensively to visualize cancer in soft tissues. However, in order to study bone metastases, the researchers had to figure out a way to enable iMPM to look inside much harder material.
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