24 February 2020

Peter Friedl, theme Cancer development and immune defense, received a 300,000 EUR grant within the NWO open call - GROOT consortium "Active matter of cancer metastasis" to identify the mechanisms of collective metastasis in breast cancer.

The consortium combines experts from biophysics, microfluidics and in silico modeling for multiscale molecular and mechanical intragration of invasion and metastasis. 

In the NWO Open Competition Domain Science - GROOT researchers can apply as a part of a consortium for curiosity-driven, fundamental research in the research fields of the NWO Domain Science.

About the project: Active matter of cancer metastasis​
During the early stages of metastasis, clusters of tumor cells combat a series of hurdles to dissociate from the primary tumor, navigate complex surrounding tissues, and enter the circulation in order to reach distant organs. In this program, they map this journey by integrating theoretical models with experimental cell biology, biophysics, and tumor biology. They aim to identify the physical/mechanical parameters that regulate collective behavior of tumor cells during these first steps of the metastatic cascade, and deliver insights for rational design of new therapeutic intervention strategies.

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