In British Journal of Radiology Rutger Stijns and colleagues, theme tumors of the digestive tract, showed that using MRI with endorectal filling did not lead to an improved rectal cancer staging and that it has the potential to influence the distance to a key anatomical landmark.ABSTRACT
To assess the influence of endorectal filling (EF) on rectal cancer staging.
47 patients who underwent a staging MRI of rectal cancer in the period from 2011 to 2014 were included. The MRI protocol included T2 weighted fast spin echo sequences without and with EF at 3 T (EF-MRI). Images were scored by two readers for T-stage, distance of the lower pole of the tumour to the anorectal junction, distance to the mesorectal fascia (MRF), and number of (suspicious) lymph nodes. Agreement in T-staging was calculated using the Cohen's κ value. Comparison of continuous variables was performed using Wilcoxon matched pairs signed-rank test.
The interobserver agreement for T-staging with and without EF-MRI showed a poor agreement between both readers (weighted κ = 0.156, weighted κ = 0.037, respectively). Tumours tended to be overstaged more prominently with EF-MRI. The accuracy of predicting the pathological T-stage slightly improved from 55% with EF to 64% without EF for Reader 1 and from 59 to 68% for Reader 2, respectively. The distance of the tumour to the anorectal junction increased from 33.9 to 49.3 mm (p < 0.001) after EF for Reader 2. EF-MRI did not significantly influence the number of (suspicious) lymph nodes and distance to the mesorectal fascia.
EF-MRI did not lead to an improved tumour staging and it has the potential to influence the distance to a key anatomical landmark. EF-MRI is therefore not recommended in primary staging rectal cancer. Advances in knowledge: EF-MRI may not be used as an additional tool to stage rectal cancer patients, as it does not seem to facilitate in locoregionally staging the disease.
The influence of endorectal filling on rectal cancer staging with MRI.
Stijns RC, Scheenen TW, de Wilt JH, Fütterer JJ, Beets-Tan RG.
Related news items
3 DCMN researchers among most cited scientists10 December 2018
Christian Beckmann, Jan Buitelaar and Barbara Franke made it to this year’s list of highly cited researchers. Scientists in this list are selected for their exceptional research performance and are regarded to have had a major impact on fellow scientists.read more
Vote for your Supervisor of the year6 December 2018
Now you have the chance to vote for your preferred candidate. Have fun, and go for it, support and promote your ideal supervisor. The winner will be announced during the RIMLS New Year's drinks on 15 January. Deadline for voting is 1 January 2019. Here is a line up of the three nominated finalists.read more
Discover Israels' secret to startup success6 December 2018
International exchange of staff is an indispensable part of one’s personal and professional growth. In the context of entrepreneurship, exciting career opportunities and networking an educational and inspiring trip to Israel is planned. You are invited to join for free (only for PhD's).read more
René Vogels Stichting travel grant for Pieter Roelofs4 December 2018
Pieter Roelofs received the award in order to perform a work visit to prof. Reuben Harris’ lab at the University of Minnesota, USA.read more
Symposium on inclusive research Monday 14 January 20194 December 2018
How does inclusive research with people with intellectual disabilities work? The academic collaborative ‘Sterker op eigen benen’ invites you to this free symposium ‘Inclusief onderzoek in ‘t eggie’ followed by the PhD defense of Tessa Frankena.read more
MRI improves detection of prostate cancer Prostate biopsy no longer necessary for 50% of male patients4 December 2018
There is good news for the more than 40,000 men per year who go to the hospital for diagnosis because of elevated Prostate-Specific Antigen (PSA) levels. “Thanks to the use of MRI, we can reduce the number of prostate biopsies by half,” says Jelle Barentsz.read more