Intestinal organoids represent a powerful system to investigate lineage specification and cellular differentiation in vitro.
In a study, recently published in Molecular Systems Biology, colleagues of the Vermeulen lab took a multi-omics approach to describe intestinal organoid differentiation at a system-wide level. This work revealed global rewiring of the epigenome, transcriptome and proteome, and identified Hnf4g as a major regulator of enterocyte differentiation.
Rik Lindeboom and Lisa van Voorthuijsen (photo), both PhD candidates in the group of Michiel Vermeulen, theme Cancer development and immune defense, worked together with the groups of Hugo Snippert and Boudewijn Burgering at the UMC Utrecht and applied a multi-omics framework on stem cell-enriched and stem cell-depleted mouse intestinal organoids to obtain a holistic view of the molecular mechanisms that drive differential gene expression during adult intestinal stem cell differentiation. This endeavor uncovered multiple layers of gene expression regulation, which contribute to lineage specification and plasticity of the mouse small intestinal epithelium.
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