29 April 2019

Polycystic liver disease is the most common extra-renal manifestation of autosomal dominant polycystic kidney disease (ADPKD). There is need for robust long-term evidence for the volume-reducing effect of somatostatin analogues.

Joost Drenth, theme Renal disorders, and colleagues, made use of data from an open-label, randomized trial to determine the effects of lanreotide on height-adjusted liver volume (hTLV) and combined height-adjusted liver and kidney volume (hTLKV) in patients with ADPKD. 

In this trial of patients with polycystic liver disease due to ADPKD, lanreotide for 120 weeks reduced the growth of liver and combined liver- and kidney volume. This effect was still present 4 months after the last injection of lanreotide. They have published their findings in the journal Gastroenterology.


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