8 December 2020

Sjoerd van DeventerAbbey Arp and Annemiek van Spriel, theme Cancer development and immune defence published in Trends in cell biology that a dynamic plasma membrane organization is a complex symphony.

Membrane protein organization is essential for proper cellular functioning and the result of a dynamic exchange between protein monomers, nanoscale protein clusters, and microscale higher-order structures. This exchange is affected by both lipid bilayer intrinsic factors, such as lipid rafts and tetraspanins, and extrinsic factors, such as cortical actin and galectins. Because membrane organizers act jointly like instruments in a symphony, it is challenging to define the 'key' organizers. Here, the researchers posit, for the first time, definitions of key intrinsic and extrinsic membrane organizers. Tetraspanin nanodomains are key organizers that are often overlooked. The researchers discuss how different key organizers can collaborate, which is important to get a full grasp of plasma membrane biology.

Figure 1. Membrane organization Is a continuous exchange affected by different organizers

read more

Related news items


Rubicon grants awarded to three RIMLS researchers

19 April 2022

Three researchers have received Rubicon funding from NWO/ZonMw. This will enable Elke Muntjewerff, Laura de Vries and Laurens van de Wiel to do research at a foreign research institute for the next two years.

read more

RIMLS awards call for nominations

19 October 2021

RIMLS awards several prizes to stimulate and honor our (young) researchers. Upcoming awards are Supervisor of the Year, Best Master Thesis, Best Publication, Best Image and more. Send your nominations now before 24 November 2021.

read more

RIMLS online award ceremony proudly presenting the winners

13 January 2021

In this special webinar of the RIMLS New Year Celebration, scientific director René Bindels reviewed 2020 and looked forward to 2021. But more importantly a number of researchers received prizes in the traditional RIMLS awards ceremony. 

read more

Controlled human malaria infection induces long-term functional changes in monocytes

3 December 2020

Robert Sauerwein and Henk Stunnenberg together with Mihai Netea and other colleagues now show for the first time that even a parasitic infection can train the immune system. The article is published in Frontiers in Molecular Biosciences.

read more

Tumor cells stimulate lipid biosynthesis in macrophages

23 September 2020

RIMLS researchers wrote in the Journal for ImmunoTherapy of Cancer that improved lipid biosynthesis in human tumor-induced macrophages contributes to their protumoral characteristics.

read more

RIMLS PhD retreat registration is open

23 January 2020

Yearly, RIMLS PhD candidates gather for the two-day PhD Retreat. Apart from the science, this event is highly valued for the opportunity to meet and get to know fellow PhD candidates during the social activities. Early bird registration and abstract submission deadline: 4 March 2020.

read more