8 April 2020

In a recent study, published in the journal Microbiome, Radboudumc researchers showed that gut microbiota from persons with attention-deficit/hyperactivity disorder (ADHD), when transplanted to mice, can cause brain alterations.

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. A possible factor causing ADHD may be the microbes in our guts. The role of gut microbiota in host physiology and health has been well established. However, whether changes in microbial composition affect the brain is unknown.

In this collaborative study between department of Anatomy and Department of Human Genetics, Anouk Tengeler and Sarita Dam examined the effects of gut microbiota on the brain. Using MRI and behavioral tests, the brain structure and function of germ-free mice colonized with microbiota from individuals with and without ADHD was assessed. They found that brain structural integrity and function was affected. While further studies with larger sample sizes are needed to fully understand the connection between gut microbiota and ADHD, these results help improve our understanding of the mechanisms connecting brain and gut in neurodevelopmental disorders. ​


Afbeelding van Tibor Janosi Mozes via Pixabay 

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