18 June 2020

Mireille Broeders of the Department for Health Evidence has been appointed full professor of Personalized Cancer Screening. This appointment became effective on 1 May 2020.

Mireille Broeders first got involved with cancer screening during her PhD project (Radboud University, 2004) where she evaluated the impact of the Nijmegen breast screening program, established already in the mid-70s of the last era. Over the past decade, she has developed a research line to identify the added value of introducing personalized risk-based approaches in the current age-based cancer screening programs, with a focus on breast cancer screening. As professor, a key question to address is whether personalized screening strategies, tailored to a person’s individual risk of cancer, are able to improve the balance of benefits and harms related to screening, both for persons at lower and higher than average risk of the cancer. To answer this question, Mireille initiated the nation-wide PRISMA study and created a unique screening cohort where all information to assess a woman’s individual risk for breast cancer has been collected prospectively from 50,000 women. The results of PRISMA will become available over the next five years and are expected to provide the basis for an evidence-based policy decision on personalized breast cancer screening in the Netherlands. Mireille: “But of pivotal importance is that we also understand whether this new personalized risk-based approach is acceptable to citizens and health professionals. Our studies so far strongly indicate that communication will be key in introducing this new approach.” Through her position at the Dutch Expert Centre for Screening (LRCB), Mireille further performs research to improve the quality of breast cancer screening.  With her team and collaborators, she explores the possibilities of introducing technological developments, particularly AI algorithms. New potential tests are becoming available rapidly and advances in AI are going particularly fast. However, in cancer screening, where millions of citizens are invited, it is essential to generate high-quality evidence that a “new” test or algorithm is also “better” when it comes to balancing  benefits and harms. In the near future, Mireille aims to apply insights gained in breast cancer screening to other established and potential new cancer screening programs, like cervical, esophageal, lung, and prostate cancer.
Mireille is Chair of the International Cancer Screening Network and contributes to the European Commission Initiative on Breast Cancer, as a member of the Guidelines Development Group.

Related news items

Increase radio- and immunotherapy efficacy by targeting hypoxia

21 January 2021

In a paper recently accepted by Clinical Cancer Research, Daan Boreel, together with Paul Span, Sandra Heskamp, Gosse Adema and Jan Bussink, reviews the therapeutic potential of decreasing the lack of oxygen (hypoxia) often found in solid tumors.

read more

Radiation boost lowers risk of prostate cancer recurrence

21 January 2021

An additional external-beam radiation dose delivered directly to the tumor can benefit the prospects of men with non-metastatic prostate cancer, without causing additional side effects. The risk of relapse within five years for these men is smaller than for men who did not receive this boost.

read more

New research through grants for Radboudumc researchers

14 January 2021

Several researchers at the Radboudumc have received grants to start new studies, including on rare diseases, liver disease and cancer metastases. These are grants from the Dutch Research Council, European Joint Programme on Rare Diseases and the Gastric Liver Disease Foundation.

read more

RIMLS online award ceremony proudly presenting the winners

13 January 2021

In this special webinar of the RIMLS New Year Celebration, scientific director René Bindels reviewed 2020 and looked forward to 2021. But more importantly a number of researchers received prizes in the traditional RIMLS awards ceremony. 

read more

Cooling vests alleviate perceptual heat strain perceived by COVID-19 nurses

11 January 2021

Wearing cooling vests during a COVID-19 shift ensures that nurses experience less heat during their work. The cooling vests offer such effective cooling that they are now part of the standard work clothing for nurses in the COVID nursing departments at Radboudumc.

read more

Hermesdorf Prizes for COVID-19 research team and Charlotte Bekker

7 January 2021

The entire COVID-19 research team at Radboudumc, which includes Frank van de Veerdonk, Mihai Netea, Roger Brüggemann, Leo Joosten and Alexander Hoischen, will receive the 2020 Hermesdorf Prize. Charlotte Bekker will be awarded the Hermesdorf Talent Prize.

read more