22 December 2020

Femke Doubrava-Simmer, theme Tumours of the digestive tract, published in Gastroenterology that in one third of the cases with more than one site of colorectal cancer (CRC), the different sites are clonally related.

In 5% of colorectal cancer (CRC) patients a second CRC develops, either synchronous or metachronous. In general, these are treated as independent primaries, suggesting these patients have an increased risk for CRC development. Using a combination of molecular techniques we showed that 33% of these multi-focal CRC are actually clonally related, and most likely develop as a result of intraluminal spread. Our results demonstrate that intraluminal spreading of CRC occurs more often than is recognized in daily practice, which affects both diagnostics and treatment of patients with multifocal CRC.

read more

Related news items

Pathology reporting of gastric endoscopic resections: Recommendations from the International Collaboration on Cancer Reporting

17 November 2021 Iris Nagtegaal, theme Tumours of the digestive tract, and colleagues published her research project in Gastroenterology about pathological reporting of gastric endoscopic resections. read more

Chella van der Post and Francesco Ciompi received a grant from Hanarth Foundation

11 November 2021 Unmasking the invisible cancer: digital detection of diffuse-type gastric carcinomas. read more

RIMLS awards call for nominations

19 October 2021 RIMLS awards several prizes to stimulate and honor our (young) researchers. Upcoming awards are Supervisor of the Year, Best Master Thesis, Best Publication, Best Image and more. Send your nominations now before 24 November 2021. read more

Young people with colorectal cancer deserve their own treatment

27 July 2021 Richarda de Voer and Marjolijn Ligtenberg's study on clinical, pathological, genetic and molecular characteristics of colorectal tumors in adolescents and adults 25 years of age or younger is published in Clinical Gastroenterology and Hepatology. read more

The international dataset for colorectal local excisions is published

16 June 2021 Iris Nagtegaal and colleagues presented their first paper on the colorectal cancer dataset and published this in the journal Gastroenterology. read more

Royal decorations for Nicoline Hoogerbrugge, Jolanda de Vries, Koos van der Velden and Jan Buitelaar

28 April 2021 Nicoline Hoogerbrugge, Jolanda de Vries, Koos van der Velden and Jan Buitelaar are appointed by His Majesty as Knight in the Order of the Dutch Lion, a highly prestigious decoration on 26 April 2021. read more