11 June 2020

Raphaël Duivenvoorden, theme Renal disorders, and colleagues, looked at the immune response of patients admitted to the hospital with a SARS-CoV-2 infection. They observed that monocytes, play an important role in the first line of defense against the coronavirus. Therefore, they investigated the effect of hydroxychloroquine on these cells. They have discovered an as yet unknown effect of hydroxychloroquine. It inhibits trained immunity, which is important in the first line of defense against infections. That is why they expect hydroxychloroquine to have no beneficial effect on the immune response in a SARS-CoV-2 infection.

They have published these findings in MedRxiv: Hydroxychloroquine inhibits trained immunity - implications for COVID-19 - Nils Rother, Cansu Yanginlar, Rik G.H. Lindeboom, Siroon Bekkering, Mandy M.T. van Leent, Baranca Buijsers, Inge Jonkman, Mark de Graaf, Marijke Baltissen, Lieke A. Lamers, Niels P. Riksen, Zahi A. Fayad, Willem J.M. Mulder, Luuk B. Hilbrands, Leo A.B. Joosten, Mihai G. Netea, Michiel Vermeulen, Johan van der Vlag, Raphaël Duivenvoorden. Articles in MedRxiv are not peer-reviewed.

Raphaël explained on the Dutch TV (NPO Op 1) about this research. You can wath this here
 

Related news items


Large AI project receives over €95 million for ten years of public-private research

23 September 2021

Radboud university medical center (Radboudumc) participates in the ROBUST consortium, which consists of 17 AI labs, eight of which are dedicated to healthcare. Radboud university medical center leads five of these eight labs.

read more

Reading ADP-ribosylation signaling using chemical biology and interaction proteomics published in Molecular Cell

22 September 2021

Kasia Kliza and Michiel Vermeulen worked on a project to synthesize biotinylated ADPr-based probes that can identify ADPr readers and determine their specificity for mono- and polyADPr. They published this in Molecular Cell.

read more

Systematic analysis of short tandem repeats in 38,095 exomes provides an additional diagnostic yield

22 September 2021

Christian Gilissen and colleagues published in Genetics in Medicine about their work guiding the application of short tandem repeat analysis in clinical exome sequencing.

read more

TropIQ seeks new mosquito repellents

21 September 2021

TropIQ Health Sciences, a Radboudumc spin-off, has received a 1.3 million USD grant from the Bill & Melinda Gates Foundation to track down new mosquito repellents.

read more

New start-up Patholyt will bring AI research into pathology diagnostics

21 September 2021

Patholyt is on a mission to accelerate the adoption of artificial intelligence in pathology diagnostics and improve the chances of cancer patients worldwide. Patholyt is a spin-off from Radboudumc, a frontrunner in computational pathology research.

read more

Treatment of most common skin cancer can sometimes wait

20 September 2021

Not treating but keeping an eye on the cancer is also an option

read more