17 May 2021

Jeroen van Doorn and colleagues published a comprehensive review on imaging of the respiratory muscles in neuromuscular disorders in the European Respiratory Journal.

Many individuals with a neuromuscular disorder (NMD), such as amyotrophic lateral sclerosis  or Duchenne muscular dystrophy  develop respiratory muscle weakness. This can lead to dyspnea, sleep problems, lung infections, and ultimately respiratory failure. Therefore, reliable  assessment of respiratory muscle function in NMDs is crucial. For patients it is of vital importance to identify early signs of respiratory insufficiency, to monitor disease progression, and to guide individual respiratory management. From a scientific perspective, relevant and reliable respiratory outcome measures are urgently needed to evaluate new gene-modifying and drug therapies. In the last decade, ultrasound (US) and magnetic resonance (MR) imaging emerged as techniques to evaluate the respiratory muscles. In their review, they discuss the latest developments in imaging of the respiratory muscles by US and MR, and its clinical application and limitations. Their goal is to increase understanding of respiratory muscle imaging and facilitate its use as an outcome measure in daily practice and clinical trials.

Through an extensive literature search they found that different US and MR imaging techniques have been successfully demonstrated to detect impaired respiratory muscle structure and function in patients with NMDs. However, a lack of standardization in measurement procedures, data on extra-diaphragmatic respiratory muscles and clinical data from natural history studies impede its widespread clinical use. In addition, new technological developments in US and MR imaging will further increase its value. Currently, they are planning a large follow-up study in patients with congenital myopathies to evaluate the value of new US techniques, such as strain imaging to measure muscle deformation and ultrafast shear wave elastography to measure muscle elasticity.

Publication

van Doorn, J. L. M., Pennati, F., Hansen, H. H. G., van Engelen, B. G. M., Aliverti, A., & Doorduin, J. (2021). Respiratory muscle imaging by ultrasound and MRI in neuromuscular disorders. Eur Respir J. doi:10.1183/13993003.00137-2021

 

Related news items


Laurens Verscheijden awarded doctorate degree 'cum laude'

19 January 2022

Laurens Verscheijden of the Department of Pharmacology and Toxicology, defended his PhD thesis, entitled "Mechanistic models for the prediction of brain drug exposure and response in the paediatric population: A virtual child reaching maturation.

read more

Aerobe exercise has a positive effect on brain function in Parkinson's disease patients

18 January 2022

Radboudumc researchers have shown that the brain function of patients with Parkinson's disease improved with regular exercise, which seems to strengthen the connections between different brain areas, while inhibiting brain shrinkage.

read more

Last call for nominations for the RIHS Awards 2021 Deadline for submission is 25 January 2022

18 January 2022

RIHS researchers are invited to propose candidates for the RIHS PhD Award, the Societal Impact Award, the Science Award, the Supervisor of the Year Award, and the RIHS Patient Involvement Award.

read more

Cause of male infertility already present in DNA before birth

17 January 2022

New mutations in DNA, which are not inherited from the father or mother but arise spontaneously before or during fertilization, can cause infertility in men.

read more

Rogier Kievit and Geert Litjens both receive ERC Starting Grant of 1.5 million euros Board of Directors congratulates researchers on top grant

13 January 2022

Researchers Rogier Kievit and Geert Litjens were today festively welcomed by the Board of Directors, because of the ERC Starting Grants they both received. With these European top grants, they can each design an ambitious research project and put together their own research group.

read more

Improved AI will boost cancer research and cancer care Geert Litjens receives ERC Starting Grant

13 January 2022

Geert Litjens from Radboud university medical center has received a European Research Council (ERC) Starting Grant.

read more