4 March 2021

Exercise lowers the risk of glucose intolerance, obesity, elevated cholesterol and hypertension. Also in patients with existing cardiovascular diseases, the risk of new cardiovascular diseases can be lowered by an individual exercise guideline, argues epidemiologist Esmée Bakker in her dissertation, on which she obtained her PhD on March 4 from Radboudumc and Liverpool John Moores University. 

Patients with heart failure or other cardiovascular diseases are generally less active than healthy people or people who belong to a risk group because of high cholesterol, diabetes or hypertension. Esmée Bakker's research shows that heart patients sit for an average of over ten hours in a day, while healthy people generally sit for nine hours. This much sitting causes health to deteriorate and the risk of death to increase. 

Strength training twice a week

To reduce the risks of cardiovascular disease, both cardiovascular patients and people without symptoms are advised to do strength training at least twice a week. Subjects who actually did this were found to reduce the risk of metabolic syndrome (combination of glucose intolerance, obesity, elevated cholesterol and hypertension) by almost twenty percent. They also looked at how much strength training lowers this risk. And what did it show? If you do less than an hour of strength training in total per week, the risk of cardiovascular disease decreases by almost thirty percent. So adding strength training to your weekly routine really does make a difference!

The fitter, the lower the risk of heart disease

Esmée Bakker also studied the influence of cardiac rehabilitation on the prognosis of patients. Patients suffering from heart failure are often less fit than healthy persons. How fit a patient is partly determines the risk of more heart disease. To lower this risk, patients can follow a cardiac rehabilitation program to get them to exercise more. This study found that patients who do not improve their physical fitness in rehabilitation have almost a two times higher risk of unexpected hospitalization or death. Almost half of heart failure patients show no improvement in fitness. Thus, especially for patients with heart failure, it is crucial to make an individual guideline so that they become more active and the further risks decrease. 

Different effects of increased exercise

Esmée Bakker: "Actually, everyone, regardless of age, benefits from more exercise. In both healthy test subjects and patients we see that they benefit most from the effects when they go from not moving to moving a little. So the risks decrease fastest in both groups especially at the beginning of the exercise program. The difference is in the long term. In cardiovascular patients the effects last longer if they continue to exercise, this is not the case in healthy individuals. Healthy individuals reach a plateau at some point. So, especially in patients, it appears the more exercise the better."

The coronavirus makes us move even less

Although the research itself was not conducted in 'corona time', it is clear that the corona virus has major consequences for our health. Bakker: "Healthy people sat for nine hours before corona. Nowadays this quickly becomes more because of working at home. By getting up for a few minutes every half hour, you can already make a difference. Regardless of your age or risk, even a little exercise helps."


About the PhD 
Thesis title: Physical Activity and Sedentary Behaviour in the Prevention of Cardiovascular Disease. Promoters: Prof. Dr. D.H.J. Thijssen (Liverpool John Moores University, United Kingdom), Prof. Dr. M.T.E. Hopman and co-supervisors Dr. T.M.H Eijsvogels and Dr. P. M. Watson (Liverpool John Moores University, United Kingdom). Esmée Bakker will receive her PhD on March 4 at 10.30 am at Radboudumc/ Radboud University. Her PhD can be followed live here. Link https://www.radboudumc.nl/agenda/2021/maart/04mar2021-promotie-esmee-bakker 

 

Related news items


New way of diagnostics detects 'undetectable' genetic defects

15 April 2021

Research provides guidance for global application

read more

Vici grant for Michiel Vermeulen Reading the epitranscriptome

15 April 2021

Michiel Vermeulen, theme Cancer development and immune defense, has been awarded a Vici grant from the Netherlands Organisation for Scientific Research (NWO), one of the largest personal scientific awards in the Netherlands.

read more

2.5 million Euros for cancer research into ovarian cancer and immunotherapy

15 April 2021

The Radboudumc receives 2.5 million Euros from the Dutch Cancer Society (KWF) for three studies to ensure oncological progress during COVID-19 period.

read more

COVID-19 regulations for nursing homes have varying effects

14 April 2021

On May 11th 2020, the Dutch Government allowed 26 nursing homes to welcome one visitor per resident, after two months of lockdown. An in-depth Radboudumc study monitored the feasibility of the regulations and the impact on the well-being of residents, their visitors, and healthcare staff.

read more

Anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity

14 April 2021

Cell reports publication by Charles Dinarello and Mihai Netea and colleagues, theme Infectious diseases and global health, shows that the anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity.

read more

ADHD-related alterations in brain organization based on different brain profiles

14 April 2021

Structural differences between the brains of people with and without ADHD are extensively reported. In accordance with earlier (ENIGMA) studies, and using a large cohort, a newly published study builds upon these by showing differences in brain organization that is based on different brain profiles.

read more