1 March 2021

Effective March 1, 2021, pediatric nephrologist Nicole van de Kar has been appointed professor of Complement-Mediated Renal Diseases at Radboud university medical center/Radboud University. Nicole van de Kar will be particularly involved in research on the rare kidney diseases hemolytic-uremic syndrome and C3 glomerulopathy.

The research of Professor of Complement-Mediated Renal Diseases Nicole van de Kar focuses on finding an optimal treatment for the two rare kidney diseases hemolytic-uremic syndrome (HUS) and C3-glomerulopathy (C3G). In both pathologies, the complement system is overactive, ultimately leading to kidney damage.

Unraveling disease mechanisms

Nicole van de Kar (1963, Ubach over Worms/Landgraaf) studied Medicine at Radboud University in Nijmegen and received her PhD with honors in 1994 on her thesis ‘Pathogenesis of the Hemolytic Uremic Syndrome in Childhood’. After completing her doctoral program, she continued her training as a pediatrician and then as a pediatric nephrologist. Van de Kar has had a permanent appointment at the Radboudumc Amalia Children's Hospital since 2000, where she does research on HUS and C3G. Her ambition is to unravel the disease mechanisms underlying these diseases, and thus improve the diagnosis and treatment of patients with HUS and C3G.

Expensive drugs, safe and responsible

Partly due to Van de Kar's research, the Radboudumc has been recognized nationally and Europe-wide as a center of expertise for HUS and C3G. It has taken on the task of using expensive orphan drugs for these diseases safely and responsibly. Partly with grants from ZonMw, Van de Kar is committed as a pediatric nephrologist, and now as a professor, to scientific research and the most optimal care for patients with HUS and C3G.