Jeroen Langereis postdocJeroen Langereis is a postdoctoral researcher at the section Pediatric Infectious Diseases at the Laboratory of Medical Immunology.
My main goal in science is to understand how bacteria colonizing the upper respiratory tract are able to cause opportunistic infections, which include otitis media, pneumonia and sepsis. Both host factors, such as the complement system and phagocytes, and bacterial virulence mechanisms have my interest. Novel virulence factors might be interesting vaccine targets to prevent infections.For the identification of bacterial virulence factors, I use genome-wide mutagenesis screens to identify the genetic architecture required for bacteria to survive in inflammatory conditions. Recently, I started genome-wide mutagenesis screens to identify bacterial genes required to grow in nutrient poor conditions such as the lungs. On the host side, I focus on the contribution of immunoglobulin M (IgM) and IgA in protection against bacterial infections, either in blood or on mucosal surfaces. My ultimate goal is to understand bacterial pathogenesis and contribute to the development of novel intervention strategies, vaccines or small molecule inhibitor that prevents or treat inflammatory diseases.
Personal prizes & awards national & international
- 2012: 1st prize Junior presenter, International congress of the European Society of Pediatric Otorhinolaryngology (ESPO), Amsterdam, the Netherlands