Joost Hoenderop full professorJoost Hoenderop is full professor of Molecular Kidney Physiology, has a background in molecular biology and obtained his Ph.D. degree in Medical Sciences at the Radboud University Nijmegen in 2000. Subsequently, he held an EMBO fellowship at the Institute of Pharmacology and Toxicology at the University of Lausanne, Switzerland.
Research interests include the regulation of Ca2+ and Mg2+ transport in epithelia with a specific focus on the molecular regulation of epithelial Ca2+ and Mg2+ channels (TRPV5&6 and TRPM6&7), members of the transient receptor potential (TRP) channels. Recent studies indicate that these channels function as gatekeepers to maintain the extracellular Ca2+ and Mg2+ balance which is crucial for mammalian development and function. His current work focuses on the functional aspects of these channels using a comprehensive approach that includes studies on epithelial cell lines and animal knockout models, identification of regulatory partners and electrophysiological analysis of channel activity.
Field of studyPhysiology
Research group Understanding tubulopathies
Joost Hoenderop's group focuses on tubular transport of calcium, magnesium and sodium by the kidney tubule and the changes therein. For acquired renal disorders, uncovering the underlying mechanism, prevention and rational treatments for drug-induced toxicities is a main focus.read more