Katarina Wolf assistant professorThe ability of cancer cells to invade surrounding tissues and metastasize to distant organs is a key hallmark of cancer, with metastasis contributing to approximately 90% of cancer related deaths. We focus on understanding biomechanical and molecular mechanisms of metastatic tumor cell dissemination, in particular how cells adapt to and change tissue space for migration within dense and heterogeneous connective tissues present in the tumor microenvironment.
Themes of interest include:
- the impact of extracellular matrix-directed proteases,
- lamin-mediated nuclear shape change including nuclear protection and envelope rupture, DNA damage and repair, and the
- the role of cell contractility for cell migration in different tissue environments and geometries.
Katarina Wolf obtained her PhD in cell biology at the University of Würzburg, Germany (2003). After working as a postdoc at the University of Würzburg and at the NCMLS, she received a VIDI grant from the Netherlands Organization for Scientific research (NWO) in 2009. She holds a tenured position as Universitair Docent (UD) and assistant professor.
Field of study