News items related to the Radboud Institute for Health Sciences.
Peter van der Kraan new theme leader Inflammatory diseases13 June 2019
It is our pleasure to introduce Peter van der Kraan from the Dept. of Rheumatology, as the new leader of our theme Inflammatory diseases. As such he will be the successor of Irma Joosten who has done an outstanding job in the last years as theme leader, for which we thank her wholeheartedly.
Intake of a reduced dose of pazopanib with food the effect on pharmacokinetics, patient safety and preference13 June 2019
In Clinical Pharmacology & Therapeutics Floor Lubberman and colleagues showed that the intake of 600mg pazopanib with food resulted in a bioequivalent exposure and was preferred over a standard pazopanib dose without food.
Developing malaria gametocytes under attack6 June 2019
In Science Translational Medicine, researchers from the group of Teun Bousema and international colleagues have revealed previously unknown targets of natural human antibody responses that are found on the surfaces of red blood cells infected with malaria parasites.
The XN-30 hematology analyzer for rapid sensitive detection of malaria a diagnostic accuracy study6 June 2019
In BMC Medicine Annelies Post, Berenger Kaboré, Isaie Reuling and colleagues described a new method of malaria detection using whole blood: the XN-30 is a new hematology analyzer which simultaneously provides a complete blood count and quantification of malaria parasitemia, allowing rapid treatment.
Barrett oesophagus6 June 2019
In Nature Reviews Disease Primers Yonne Peters and Ali Al-Kaabi provided a global overview of Barrett oesophagus and outlined key open research questions. This primer covered epidemiology, disease mechanism, diagnose, screening, prevention, management, and quality of life.
Jeroen Hasselaar elected board member European Association for Palliative Care6 June 2019
On 24 May at the congress for palliative care in Berlin, Jeroen Hasselaar has been elected as a board member of the European Association for Palliative Care (EAPC), for the period 2019-2023. Jeroen was nominated on behalf of the Dutch association for palliative care (Palliactief).
1.6 million euros for Radboud university medical center in new study into shorter tuberculosis treatment5 June 2019
The study is meant to reveal whether a shorter treatment using a new combination of four different antibiotics could be as effective as the regular, longer treatment for tuberculosis (TB).
Ingenious solution, but what was the problem?29 May 2019
In Value in Health Anouck Kluytmans, Marcia Tummers, Gert Jan van der Wilt and Janneke Grutters found, using a mixed methods approach, that although a recently developed medical technology was deemed ingenious by stakeholders, there was no underlying problem it could solve in its intended context.
Graduate school news Adjusted PhD guidelines23 May 2019
It should be emphasized that the quality, and not the number of chapters, determines the assessment by the manuscript committee. To avoid the wrong emphasis on quantity, it is not recommended to have more than three publishable chapters in the thesis.
Stress among PhD candidates23 May 2019
Do you struggle with too much stress at work or with your PhD project and is there a high workload? Are there problems with your supervisor or a colleague that you cannot resolve? Do you miss a balance between work and private life? Then make an appointment with one of our Radboudumc counselors.
How do we keep new technology affordable to improve the lives of people?16 May 2019
Improving healthcare by means of new technological developments? We need to change the entire approach for evaluating the true impact , says Maroeska Rovers. By bringing together all stakeholders from the beginning, millions of euros can be saved.
Algorithm calculates the presence and aggressiveness of prostate tumors14 May 2019
A computer program that analyzes MRI images can reliably map the presence and even the aggressiveness of a prostate tumor. This is what Radboudumc researchers and international colleagues have published in the scientific journal Investigative Radiology.
Universal tumor BRCA1/2 testing of ovarian cancer13 May 2019
Marjolijn Ligtenberg, Janet Vos and Nicoline Hoogerbrugge, assessed the feasibility of a workflow for universal tumor DNA BRCA1/2 testing of all newly diagnosed OC patients as prescreen for PARPi treatment and cancer predisposition testing. They have published their findings in the JNCI.
Association of gestational weight gain with adverse maternal and infant outcomes13 May 2019
An individual participant meta-analysis published in JAMA showed that pregnancy BMI is related stronger to maternal and infant complications than to gestational weight gain. The PRIDE Study, with coauthors Marleen van Gelder and Nel Roeleveld, was one of the participating cohorts.
Minocycline to treat pulmonary Mycobacterium avium complex disease9 May 2019
In Journal of Antimicrobial Chemotherapy Mike Ruth, Jakko van Ingen and colleagues showed that minocycline may be useful to treat pulmonary diseases caused by Mycobacterium avium complex bacteria. This is important as few drugs are active against this disease and treatment outcomes are very poor.
Health insurers make few reallocations impacting hospital budgets2 May 2019
A financial analysis of the annual reports of Dutch hospitals has shown that only 2 - 3 percent of the total budget was reallocated in 2007-2014. This was the conclusion of PhD research by Niek Stadhouders of Radboudumc, which he defended on 15 April.
Removal of sialic acid from platelets responsible for thrombocytopenia in dengue23 April 2019
In the PLoS Pathogens Quirijn de Mast and his colleagues showed that excessive binding of the coagulation protein von Willebrand factor leads to removal of sialic acid from platelets and platelet clearance.
Prophylactic antibiotics reduce hospitalisations and cost in head and neck cancer patients18 April 2019
In European journal of cancer Janneke Ham and colleagues showed that prophylactic antibiotics in locally advanced head and neck cancer patients treated with chemoradiotherapy did not reduce the incidence of (aspiration) pneumonias, but did reduce hospitalisations and tended to be cost-effective.
Nontuberculous mycobacteria and fungal co-infections Bonnie and Clyde?18 April 2019
In The European respiratory journal Jakko van Ingen and Sanne Zweijpfenning showed that 40% of patients diagnosed with nontuberculous mycobacterial pulmonary disease also meet diagnostic criteria for chronic pulmonary aspergillosis.
Dosing anticancer drugs in patients with renal or hepatic impairment11 April 2019
Renal or hepatic impairment is a common comorbidity for patients with cancer either because of the disease itself, toxicity of previous anticancer treatments, or because of other factors affecting organ function, such as increased age.
Judith Prins appointed scientific director of RIHS a.i.5 April 2019
Judith Prins, full professor of Medical Psychology and prominent principal investigator, has been appointed scientific director ad interim (a.i.) of the RIHS as of 1 April. She succeeds Bart Kiemeney after his RIHS directorship of more than seven years.
Pim Assendelft on NFU report ‘Research and innovation with and for a healthy region’5 April 2019
On 1 April the report ‘Research and innovation with and for a healthy region; think globally, act locally’ was handed by the Federation of University Medical Centers (NFU) to Minister Bruins of Healthcare.
800k Euro for research project effectiveness ‘Healthy School’4 April 2019
The Dutch government has started the project ‘Gezonde school’ (‘Healthy School’). Schools can achieve this vignette if they devote time and attention to the health and healthy lifestyle of students on the basis of the ‘Healthy school approach’.
Impulsivity and infectious diseases among female prisoners in Indonesia Knowledge transfer alone not sufficient for controlling infectious diseases28 March 2019
Unprotected sexual contact and intravenous drug use are important routes of infection for infectious diseases such as HIV, hepatitis B and C and syphilis.