Numerous grants were acquired by our outstanding researchers. We are delighted with these accomplishments. The most significant grants awarded in 2019 are represented on this page.

RIMLS highlights 2019

Biodegradable patches for children with congenital diaphragmatic hernia

Willeke Daamen and Toin van Kuppevelt received together with University of Twente a 690 kEuro grant of the Netherlands Organization for Scientific Research (NWO) for the development of advanced patches for closure of diaphragmatic defects in children with congenital diaphragmatic hernia.

15 Million Euro to discover new avenues to fight the HIV virus

“This is a unique, first-time collaboration which will combine in-depth clinical and pathophysiological phenotyping with a systems biology approach in a large population of patients with HIV.”

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15 Million Euro to discover new avenues to fight the HIV virus

André van der Ven, Mihai Netea and colleagues, received 15 mEuro from the pharmaceutical company ViiV Healthcare to discover new avenues to fight the HIV virus. The aim of the HIV 2000+ project is to identify new drug targets for HIV. This collaboration will process anonymised patient data, genetic information and environmental factors in order to understand the biology associated with HIV better and identify targets for new medicines earlier. 
 
ViiV Healthcare is announcing a five-year collaboration with researchers of the Radboudumc, providing dedicated funding to enhance the HIV-specific capability of the Human Functional Genomics Project (HFGP). The HFGP is a large-scale project that combines detailed patient data with cross-omics information, host immune responses and environmental factors to better understand how the body recognizes and defends itself from disease as well as the signs, symptoms and progression of disease.
 
Under the supervision of a Scientific Management Board (SMB) comprising representatives from Radboudumc and ViiV Healthcare, Radboudumc will expand the cohort of HIV-infected individuals that are part of the HFGP from 200 to 2000 people. Data from this cohort will be used to look at the predictors and pathways of diseases that are specific to people living with HIV and how they might differ from other disease areas and from healthy people who do not have HIV. Using that information, the goal is to identify early stage drug targets that ViiV Healthcare could use to develop new medicines or approaches to treat HIV infection.
 
The project, called “HIV 2000+” will be the first comprehensive cohort study in HIV to use a field of biology called 'cross-omics,' which uses genomics, microbiome metagenomics and metabolomics technologies to better understand the underlying biology associated with HIV infection.
 
Jan van Lunzen, MD PhD, Head of Translational Medical Research at ViiV Healthcare and project coordinator said: “This project will enable us to establish one of the best characterized cohorts of people living with HIV in the world and will not only help to better define biomarkers and pathways of disease progression, but may also serve as a fantastic platform to find new drug targets.”
The collaboration will combine Radboudumc’s experience in infectious diseases, established networks and scientific techniques with ViiV Healthcare’s expertise and innovation in discovering and developing medicines for HIV.
 
Mihai Netea said: “This is a unique, first-time collaboration which will combine in-depth clinical and pathophysiological phenotyping with a systems biology approach in a large population of patients with HIV. It is a unique chance to understand the HIV infection and its complications better, and to partner with ViiV Healthcare to translate that knowledge to the bed of the patient.”
 
 

H2020 FET open grant for Frank Walboomers and Ronald Bartels

The FET Open supports research into radically new technologies. Frank and Ronald received the grant for their research into graphene biomaterials.

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H2020 FET open grant for Frank Walboomers and Ronald Bartels

Frank Walboomers and Ronald Bartels have received a 500 kEuro grant for research into graphene biomaterials from the Europan Union Horizon 2020 FET Open programme.
 
The FET Open supports research into radically new technologies. Spinal cord injury (SCI) is a devastating pathology with dramatic lifetime consequences affecting thousands of people worldwide. Considering the very limited regeneration ability of the central nervous system, the project will be focusing on the development of a neural tissue engineered scaffold capable of not only combining fibrous and porous topographic cues in order to mimic the morphology of the native spinal cord, but also potentiating the properties of graphene related materials (GRM). The obtained 3D microenvironment should present electrical, chemical, mechanical and topographic features able to preserve neural cell survival and enhance neural progenitor cell differentiation towards neuronal and glial cells.
 
The grant is part of a multidisciplinary pan European consortium and within the Radboudumc will join the specific expertises in Biomaterials and Neurosurgery to have a significant impact on healthcare.
 

ReumaNederland grant for Peter van der Kraan

Peter van der Kraan received 500 kEuro to study osteoarthritis. He is also awarded the title Research Center of Excellence by ReumaNederland.

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ReumaNederland grant for Peter van der Kraan

Peter van der Kraan received 500 kEuro to study cartilage damage and pain in knee osteoarthritis. Osteoarthritis is the most common rheumatic disorder. This project will form the basis for new treatments that help to reduce cartilage damage and pain due to osteoarthritis. The research group of Peter van der Kraan is also awarded the title Research Center of Excellence by ReumaNederland.
 
With the Research Centers of Excellence at the forefront of osteoarthritis research, ReumaNederland aims to improve the treatment of people with osteoarthritis. Osteoarthritis affects nearly 1.4 million people in the Netherlands. Treatments are currently limited to lifestyle advice, pain relief and exercise therapy and, in the worst case, a prosthesis. In the coming period, a total of seven university research groups in the Netherlands will be named Research Centers of Excellence for osteoarthritis. Reuma Nederland provides a total of 3.8 mEuro for the Osteoarthritis Research Centers.
 

H2020 infrastructure development grant for a new EATRIS flagship project on personalized medicine

EATRIS, the European infrastructure for translational medicine, obtained funding for a new flagship project for sustainability and personalized medicine: EATRIS-Plus. Alain van Gool, Peter-Bram ‘t Hoen and Ariaan Siezen are co-PI’s.

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H2020 infrastructure development grant for a new EATRIS flagship project on personalized medicine

EATRIS, the European infrastructure for translational medicine, obtained funding for a new flagship project for sustainability and personalized medicine: EATRIS-Plus. Alain van Gool (Mitochondrial diseases), Peter-Bram ‘t Hoen (Nanomedicine) and Ariaan Siezen received 550 kEuro from this 5 million Euro Horizon2020 infrastructure development grant.
 
The project aims to build further capabilities and deliver innovative scientific tools to support the long-term sustainability of EATRIS. A key output of the project will be the piloting and delivery of a multi-omic toolbox, that will include SOPs, guidelines for best practices, reference materials, quality parameters, analysis tools, criteria for establishing reference values, and will provide access to a repository of multi-omic data. Objectives that are in line with the ambitions of the Netherlands X-omics Initiative, coordinated by Alain van Gool.
 
EATRIS covers over 90 institutes across Europe, among which Radboudumc. It has shown strong proof of concept of the value and utility of its translational medicine services portfolio, with users including academia, SMEs, large pharma, biotech and research funding organizations. The overarching aim of EATRIS-Plus is to further support the long-term sustainability of EATRIS by delivering innovative scientific tools to the personalized medicine research community. EATRIS-Plus will help pooling and utilising the translational academic capacities of the infrastructure in omics technologies to enable researchers to better address the scientific and societal challenges of personalized medicine.
 

List of grants

A selection of other grants obtained by our RIMLS researchers is presented here.

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List of grants

Cancer development and immune defense

Niels Stensen Fellowship: Converting tumors from ‘cold’ to ‘hot’: Controlled release of immune cell-recruiting factors from engineered biomaterials. Jorieke Weiden
Total grant: 58 kEuro. Awarded Radboudumc: 58 kEuro.
 
KWF (Dutch Cancer Society) grant: Immunotherapy meets Radiotherapy: understanding cGAS to define immunogenic vs non‐immunogenic radiation conditions. Gosse Adema
Total grant: 580 kEuro. Awarded Radboudumc: 580 kEuro.
 
KWF (Dutch Cancer Society) grant: Induction of neo-antigen specific T cells by specialised cross-presenting dendritic cells in epithelial ovarian cancer patients. Jolanda de Vries
Total grant: 657 kEuro. Awarded Radboudumc: 657 kEuro.
 
NWA-IDG grant: Cancer immunotherapy. Paul de Jonge and Harry Dolstra
Total grant: 50 kEuro. Awarded Radboudumc: 50 kEuro.
 
Grant Stichting Kinderen Kankervrij (KiKa): Dendritic cell vaccines to ptevent cancer in Constitutional Mismatch Repail Deficiency. Gerty Schreibelt
Total grant: 125 kEuro. Awarded Radboudumc: 125 kEuro.

Infectious diseases and global health

ZonMw TOP grant: Molecular mechanisms underlying dormancy of malaria parasites. Richard Bartfai and Clemens Kocken
Total grant: 675 kEuro. Awarded Radboud University: 340 kEuro.
 
NWO ENW XS grant: Defining the regulatory circuit that drives early development of virus-transmitting mosquitoes. Ronald van Rij
Total grant: 50 kEuro. Awarded Radboudumc: 50 kEuro.
 
NWO grant: Netherlands Centre for One Health. Ronald van Rij and Pascal Miesen
Total grant: 10 mEuro. Awarded Radboudumc: 585 kEuro.
 
Leo Foundation grant: This project aims to study the biology of Late Cornified Envelope genes and to translate these findings to the understanding of psoriasis pathogenesis. Patrick Zeeuwen and Ellen van den Bogaard
Total grant: 341 kEuro. Awarded Radboudumc: 341 kEuro.
 
ViiV Healthcare grant: The aim of the HIV 2000+ project is to identify new drug targets for HIV. André van der Ven and Mihai Netea
Total grant: 15 mEuro. Awarded Radboudumc: 15 mEuro.
 
MRC Welcome Trust: PROTID: Randomised controlled trial of preventive treatment of latent tuberculosis infection in patients with diabetes mellitus. Reinout van Crevel, Rob Aarnoutse, Lindsey te Brake and Elin Svensson
Total grant: 4 mEuro. Awarded Radboudumc: 252 kEuro.
 
Grant La Caixa: Frank van der Veerdonk
Total grant: 999 kEuro. Awarded Radboudumc: 68 kEuro.

Inflammatory diseases

ZonMW grant: Doen of Laten: het bevorderen van gepaste zorg. Irma Joosten
Total grant: 3 mEuro. Awarded Radboudumc: 2 kEuro.
 
ReumaNederland grant: Development of cartilage damage and pain in knee osteoarthritis. Peter van der Kraan
Total grant: 500 kEuro. Awarded Radboudumc: 500 kEuro.
 
Dutch Arthritis Association (RheumaNederland) for Experimantal Rheumatology: xiocus on novel tools for imaging of early synovial activation for diagnostic and therapeutic purposes in osteoarthritis. Peter van Lent
Total grant: 160 kEuro. Awarded Radboudumc: 160 kEuro.
 
Dutch Arthritis Association (RheumaNederland) for Experimantal Rheumatology: The role of TAM receptor tyrosine kinases in osteoarthritis and treat this disease by activating this negative feedback system. Fons van de Loo
Total grant: 160 kEuro. Awarded Radboudumc: 160 kEuro.
 
REFIT from Hartstichting and LSH topsector: Restore with extracellular vesicles the function of the intestinal Tract. Fons van de Loo
Total grant: 228 kEuro. Awarded Radboudumc: 147 kEuro.

Nanomedicine

Stichting Stofwisselkracht grant: Identification of immune-related symptoms in congenital disorders of glycosylation. Paola de Haas, Alessandra Cambi and Dirk Lefeber
Total grant: 25 kEuro. Awarded Radboudumc: 25 kEuro.

Reconstructive & regenerative medicine

ZonMW grant: PLUGGING THE GAP: An enabling technology to prevent rupture of fetal membranes in fetal endoscopic surgery. Willeke Daamen
Total grant: 1.3 mEuro. Awarded Radboudumc: 1.3 mEuro.
 
NWO AES grant. Superior bone regeneration induced by sustained mRNA delivery from colloidal biomaterials - RNA4Bone. Sander Leeuwenburgh and Ronald Brock
Total grant: 581 kEuro. Awarded Radboudumc: 581 kEuro.
 
NWO AES grant. Development of advanced patches for closure of diaphragmatic defects in children with congenital diaphragmatic hernia. Willeke Daamen and Toin van Kuppevelt
Total grant: 690 kEuro. Awarded Radboudumc: 370 kEuro.
 
Rotary Ridderkerk - de Waalf fund: Developing improved biomaterials and treatment modalities for children with this congenital birth defect. Sanne Botden, Ivo de Blaauw and Willeke Daamen
Total grant: 51 kEuro. Awarded Radboudumc: 51 kEuro.

Rare cancers

KWF 2019-2 grant: CAIX-targeted alpha therapy for tumor specific radiation of metastatic clear cell renal cell carcinoma. Sandra Heskamp
Total grant: 662 kEuro. Awarded Radboudumc: 662 kEuro. 

Renal disorders

NWO ENW XS grant: Novel peptide therapeutic to fight kidney stones. Jenny van der Wijst
Total grant: 50 kEuro. Awarded Radboudumc: 50 kEuro.
 
Dutch Kidney Foundation Innovation grant: Salt supplementation in Gitelman syndrome: A simple intervention using an innovative N-of-1 trial approach. Tom Nijenhuis
Total grant: 100 kEuro. Awarded Radboudumc: 100 kEuro.
 
Innovation Grant of the Dutch Kidney Foundation (Nierstichting): The HNF1B switch: Single-cell RNA sequencing to unravel renal cyst formation in ADTKD-HNF1B. Jeroen de Baaij
Total grant: 100 kEuro. Awarded Radboudumc: 100 kEuro.
 
Dutch Kidney Foundation grant: From rare diseases to the general population. Jeroen de Baaij and Joost Hoenderop
Total grant: 260 kEuro. Awarded Radboudumc: 260 kEuro.

Tumors of the digestive tract

KWF 2019-2 Implementatie grant: Tumor-First-werkwijze: landelijke implementatie vangenetische diagnostiek op eierstokkankerweefsel om patiënten te selecteren voor erfelijkheidsonderzoek en persoonsgerichte therapie. Nicoline Hoogerbrugge
Total grant: 750 kEuro. Awarded Radboudumc: 750 kEuro.
 
KWF 2019-2 grant: Tumordeposities: de oorzaak van metastasen? Iris Nagtegaal
Total grant: 705 kEuro. Awarded Radboudumc: 705 kEuro.
 
KWF-2019-2 UHRP grant: Bacterial biofilms to improve detection of right-sided precursor lesions. Annemarie Boleij
Total grant: 167 kEuro. Awarded Radboudumc: 167 kEuro.
 
KWF (Dutch Cancer Society) grant: Dissecting the role of aberrant E-cadherin signaling in the initiation and progression of diffuse-type gastric cancer. Chella van der Post
Total grant: 653 kEuro. Awarded Radboudumc: 653 kEuro.
 
KWF (Dutch Cancer Society) grant: Identification of genetic cancer predisposition through tumour genome mutational profiling. Richarda de Voer
Total grant: 566 kEuro. Awarded Radboudumc: 566 kEuro.
 
 

Horizon 2020 grants

A selection of Horizon 2020 grants obtained by our RIMLS researchers is presented here.

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Horizon 2020 grants

Inflammatory diseases

H2020 grant: ImmUniverse: Better control and treatment of immune-mediated diseases by exploring the universe of microenvironment imposed tissue signatures and their correlates in liquid biopsies. Irma Joosten
Total grant: 15.5 mEuro. Awarded Radboudumc: 1.1 mEuro.
 
H2020 grant: Brain injury in the premature born infant: stem cell regeneration research network (PREMSTEM). Renate van der Molen
Total grant: 9 mEuro. Awarded Radboudumc: 322 kEuro.
 
H2020 grant: BIOMAP (Biomarkers in Atopic Dermatitis and Psoriasis). Ellen van den Bogaard
Total grant: 10.5 mEuro. Awarded Radboudumc: 258 kEuro. 

Infectious diseases and global health

H2020 grant: Coordinator of an international consortium to screen thousands of people with diabetes in Uganda and Tanzania for TB, and investigate the effect and costs of 3 months preventive treatment for TB. Reinout van Crevel and Lindsey te Brake
Total grant: 4.8 mEuro. Awarded Radboudumc: 2 mEuro.
 
H2020 grant: Personalized immunotherapy in sepsis: a precision medicine-based approach (Immunosep). Mihai Netea
Total grant: 10 mEuro. Awarded Radboudumc: 1.6 mEuro.
 
H2020 grant: Host-targeted approaches for the prevention and the treatment of Hospital-Acquired Pneumonia (HAP2). Mihai Netea
Total grant: 10 mEuro. Awarded Radboudumc: 785 kEuro.
 
H2020 grant: Diagnosis and management of febrile illness using RNA personalized molecular signature diagnosis (DIAMONDS). Marien de Jonge
Total grant: 22.6 mEuro. Awarded Radboudumc: 400 kEuro.
 
H2020 grant: Prevention of antibiotic resistance by TARGEted Treatment of pneumonia in children. Marien de Jonge and Quirijn de Mast
Total grant: 787 kEuro. Awarded Radboudumc: 299 kEuro.
 
H2020-MSCA-ITN.grant: Deciphering the fungus-host-microbiota interplay to improve the management of fungal infections. Mihai Netea
Total grant: 3.5 mEuro. Awarded Radboudumc: 266 kEuro.
 
H2020-MSCA-ITN.grant: Cell2Cell: What makes a successful pathogen: Understanding the impact of cell-to-cell heterogeneity in chromatin structure on infection and adaptation. Richard Bartfai
Total grant: 3.9 mEuro. Awarded Radboud University: 266 kEuro.
 
H2020 grant: Revolutionizing healthcare by ytracking and understanding human cells during disease. Mihai Netea
Total grant: 1 mEuro. Awarded Radboudumc: 2.5 kEuro.

Mitochondrial diseases (Metabolic disorders)

H2020 grant: PD-MitoQUANT consortium. Werner Koopman
Total grant: 4.5 mEuro. Awarded Radboudumc: 400 kEuro.

Nanomedicine

H2020 grant: HDM-FUN: Host directed medicine in invasive fungal infection. Frank van de Veerdonk
Total grant: 10 mEuro. Awarded Radboudumc: 2,8 mEuro.
 
H2020 grant: EATRIS-Plus. Consolidating the capacities of EATRIS-ERIC for Personalised Medicine. Alain van Gool, Peter-Bram ’t Hoen, Ariaan Siezen
Total grant: 5 mEuro. Awarded Radboudumc: 550 kEuro.
 
H2020 grant: ReCognitION: Recognition and Validation of Druggable Targets from the Response to Cognitive Behaviour Therapy in Myotonic Dystrophy type 1 patients from Integrated -Omics Networks. Peter-Bram ‘t Hoen, Baziel van Engelen and Jeffrey Glennon
Total grant: 1.3 mEuro. Awarded Radboudumc: 250 kEuro. 

Reconstructive and regenerative medicine

H2020 FET open grant: Neurostimspinal: A step forward to spinal cord injury repair using innovative stimulated nanoengineered scaffolds. Frank Walboomers
Total grant: 3.5 mEuro. Awarded Radboudumc: 500 kEuro.
 
H2020Grant: European Commission 3HP. Wout Feitz
Total grant: 600 kEuro. Awarded Radboudumc: 600 kEuro. 

Renal Disorders

H2020 grant: SCilS - Studying ciliary signaling in development and disease. Ronald Roepman
Total grant: 3.7 mEuro. Awarded Radboudumc: 531 kEuro. 

Tumours of the digestive tract

H2020 grant: European Commission CEF 2018 (190180). Nicoline Hoogerbrugge
Total grant: 100 kEuro. Awarded Radboudumc: 100 kEuro.
 
H2020 grant: Improving diagnostics and grasping the disease mechanisms of rare hypomagnesemia in patients with CNNM2 mutations. Joost Hoenderop
Total grant: 1 mEuro. Awarded Radboudumc: 250 kEuro.
 

 


Personal grants

A selection of personal grants obtained by our RIMLS researchers is presented here.

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Personal grants

Dekker grant

Trained innate immunity at the level of bone marrow progenitors as driver of atherosclerosis development. Siroon Bekkering, Vascular damage
Awarded: 209 kEuro. 

EMBO fellowship

RegulatioNFkB: Deciphering transcriptional regulation of NF-kB target genes using integrative omics approaches. Katarzyna Kliza,  Cancer development and immune defense
Awarded: 77 kEuro. 

ERC – Advanced

A new approach to immunotherapy. Carl Figdor, Cancer development and immune defense
Awarded: 2,5 mEuro.
 
Improving vaccinations for the elderly. Mihai Netea, Infectious diseases and global health
Awarded: 2,5 mEuro. 

ERC Proof of Concept grant

Ex vivo cell labeling for in vivo imaging applied to cell therapy. Mangala Srinivas, Nanomedine
Awarded: 150 kEuro. 

Kolff Junior postdoc grant

PRednisOne effectS on Podocytes; rEsolving the moleculaR enigma - The PROSPER stud. Jitske Jansen, Renal disorders
Awarded: 225 kEuro. 

Kolff Senior postdoc grant

Innate immune-regulating nanotherapy for renal transplantation. Raphael Duivenvoorden, Renal disorders
Awarded: 375 kEuro. 

KWF Young Investigator grant

Imaging tumor infiltrating CD8+ T‐cells in non‐small cell lung cancer patients. Erik Aarntzen, Tumors of the digestive tract
Awarded: 365 kEuro.

Marie Curie Individual fellowship

RegulatioNFkB: Deciphering transcriptional regulation of NF-kB target genes using integrative omics approaches. Irene Santos, Cancer development and immune defense
Awarded: 187 kEuro.

NWO Rubicon

Linda is traveling to the United Kingdom, Newcastle University, Campus for Ageing and Vitality. Linda Heskamp, Urological cancers
Awarded: 100 kEuro.

NWO – Veni

The role of the anti-inflammatory cytokines interleukin-37 and IL-38 for innate immune memory. Rob Arts, Infectious diseases and global health
Awarded: 250 kEuro.
 
The secret lives of parasites in hepatocytes during malaria infection. Annie Yang, Infectious diseases and global health
Awarded: 250 kEuro.
 
Alarmed monocytes with Janus-faced behavior as the driving force behind OA pathology. Martijn van den Bosch, Inflammatory diseases
Awarded: 250 kEuro.
 
The REPAIR study: Regeneration of kidnEy ePitheliAl cells crossIng boRders. Jitske Jansen, Renal disorders
Awarded: 250 kEuro. 

NWO – Vidi

The malaria parasite’s fight against our immune system. Matthijs Jore, Cancer development and immune defense
Awarded: 800 kEuro.
 
How Intelligent is the Immune System? Johannes Textor, Infectious diseases and global health
Awarded: 800 kEuro.
 
Restoring the immune system to prevent cancer from spreading. Daniele Tauriello, Tumors of the digestive tract
Awarded: 800 kEuro.