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Radboud Institute for Molecular Life Sciences Organization Research groups
Overview of research groups connected to RIMLS. You can filter the list with regard to keywords, research themes and research departments.
Results (25)

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Bone biochemistry

Nico Sommerdijk’s group focuses on the mechanisms of bone biomineralization in both physiological and pathological situations.

Chemical immunology

Carl Figdor's research group studies chemical biology with a focus on the targeting of Dendritic Cells and a focus on developing synthetic Dendritic Cells to directly activate T cells.

Comparative genomics

Martijn Huijnen's research group exploits the wealth of ‘omics data to predict the function of proteins and their involvement in protein complexes and pathways. It thereby specifically focuses on the molecular systems that are of biomedical relevance.

Dendritic cell vaccination

Jolanda de Vries's research group focuses on dendritic cell vaccination. Dendritic Cell (DC) therapy represents a promising immunotherapeutic approach for the treatment of cancer.

Engineered proteins for drug delivery

Wouter Verdurmen’s research group focuses on designing and investigating engineered proteins that overcome delivery barriers, employing synthetic binding proteins for target recognition. Various (super-resolution) microscopy techniques as well as microfluidic tumor-on-a-chip approaches are used.

Experimental virology

Ronald van Rij's group studies virus-host interactions in both mosquito vector and mammalian host. By doing so, we hope to gain insights into arbovirus transmission and contribute to the development of novel antiviral therapy.

Genome bioinformatics

Christian Gilissen's group develops and applies bioinformatics methods to gain insight into the causes and mechanisms of genetic disorders such as intellectual disability.

Genomic technologies & immuno-genomics

Alexander Hoischen's research group focuses on the application of latest genomic technologies to understand human disease. A particular emphasis is put in the understanding of genetic defects that explain immune diseases, in particular primary immunodeficiencies.

Human papillomaviruses (HPV)

Willem Melchers's research aims to improve the nationwide cervical cancer screening, with the possibility of using self sampling. Important herein is research on the use of new triage methods for hrHPV positive women, by using HPV genotyping or molecular biomarkers.

Immune cell signaling

Annemiek van Spriel's research group aims to understand how immune cells physically organize and compartmentalize signaling molecules into efficient, regulated membrane-proximal signaling complexes.

Magnesium in health and disease

Jeroen de Baaij's research group examines the role of magnesium in health and disease. Our mission is to decipher the pathophysiological mechanisms of magnesoium-wasting tubulopathies by development of novel disease models and advanced methods to measure magnesium transport.

Malaria research

Teun Bousema's, Benjamin Mordmüller's and Taco Kooij's research group focuses on the clinical development of plasmodium falciparum vaccines for control and elimination of malaria.

Molecular biology of ciliopathies

Ronald Roepman's group aims to generate detailed parts lists of the molecular machines that are active in the cilia, and identify either their structural role in the cilium, or their role in the signaling pathways that are dependent on/directed by cilia.

Molecular physiology

Joost Hoenderop’s group focuses on understanding tubulopathies. The focus is on the tubular transport of calcium, magnesium and sodium by the kidney tubule and the changes therein.

Multiscale imaging

Mangala Srinivas's research group focuses on new types of contrast agents for multiple types of imaging.

Mycology

Paul Verweij's research group is primarily focused on fungal infections. We aim to develop methods for rapid and reliable identification of fungal infections in order to start early treatment and therefore improve the outcome for patients.

Nephropathology research group

Bart Smeets's research group aims to unravel the molecular processes underlying kidney regeneration and to identify new treatment targets to attenuate kidney disease progression.

Pharmacology and toxicology

Frans Russel's research group develops computational models that predict fetal-maternal drug exposure in pregnancy and brain penetration of drugs in adults and children.

Polycystic liver disease

Joost Drenth's group aims to discover novel paradigms for effective treatment of patients. Our strategy starts with disease gene discovery followed by functional studies to understand cellular pathogenesis. The main focus is polycystic liver disease, a rare inherited liver disorder.

Regenerative biomaterials

Sander Leeuwenburgh's research group focuses on developing advanced tissue regenerative therapies, utilizing biomaterials either or not combined with biological components. These therapies exploit biomaterial properties, patient-derived cells or therapeutic molecules to empower their functionality.

Renal electrolyte handling

René Bindels' research group studies the regulation of ion transport processes in kidney and small intestine in health and disease. Current projects involve the molecular mechanisms underlying rare tubulopathies and the regulation of the newly identified calcium, magnesium and sodium transporters.

Structural bioinformatics

Li Xue's and Hanka Venselaar's research group uses the information obtained from 3D-protein structures and homology models to answer (bio) medical questions. To do so, they work on the validation, improvement, and interpretation of protein structures.

Targeted nanomedicines

Roland Brock’s group focuses on the targeted delivery of molecules such as oligonucleotides, toxins and photosensitizers to modulate cell function and/or induce cell death. This research involves fundamental studies of formulation strategies and uptake mechanisms as well as preclinical applications.

Translational CRC research

Daniele Tauriello's, Henk Verheul's, Nielka van Erp's and Iris Nagtegaal's research group is a cross-disciplinary research collaboration of four Radboudumc groups, with the aim of advancing clinical translation for colorectal cancer.

Tumor micro­environment

Carl Figdor's research group tries to develop novel prognostic and predictive biomarkers, by studying tumor and blood samples from patients treated with dendritic cell (DC) vaccines. An in vitro 3D-Skin model was built to systematically study tumor- microenvironment interactions.