Overview of research groups connected to RIMLS. You can filter the list with regards to research theme and research department.
Computational approaches to advance personalized medicine
Peter Bram 't Hoen's research group develops computational approaches that exploit molecular –omics data in combination with clinical data to better understand disease mechanisms and to advance patient diagnosis and stratification for therapeutic and life style interventions.
Jo Zhou's group aims to establish disease models using patient material and model organisms to identify regulatory networks and disease mechanisms in developmental disorders. Using genomics technology, we map the genome-wide atlas of disease-associated regulatory elements beyond the coding regions.
Ion channels and calcium signaling: a matter of structure, function, and regulation
Jenny van der Wijst's research group works on the regulation of epithelial calcium transport, with a fundamental focus on the electrophysiological analysis combined with the biochemistry of ion channels and cell signaling.
Magnesium in health and disease
Jeroen de Baaij's research group examines the role of magnesium in health and disease. Our team studies the regulation of magnesium handling by the intestine and the kidney, as well as the role of magnesium in disease including diabetes mellitus type 2 and chronic kidney disease.
Polycystic liver disease
Joost Drenth's group aims to discover novel paradigms for effective treatment of patients. Our strategy starts with disease gene discovery followed by functional studies to understand cellular pathogenesis. The main focus is polycystic liver disease, a rare inherited liver disorder.
Renal electrolyte handling
René Bindels' research group studies the regulation of ion transport processes in kidney and small intestine in health and disease. Current projects involve the molecular mechanisms underlying rare tubulopathies and the regulation of the newly identified calcium, magnesium and sodium transporters.
Carl Figdor's research group tries to develop novel prognostic and predictive biomarkers, by studying tumor and blood samples from patients treated with dendritic cell (DC) vaccines. An in vitro 3D-Skin model was built to systematically study tumor- microenvironment interactions.
Joost Hoenderop's group focuses on tubular transport of calcium, magnesium and sodium by the kidney tubule and the changes therein. For acquired renal disorders, uncovering the underlying mechanism, prevention and rational treatments for drug-induced toxicities is a main focus.