Research Departments Center for Molecular and Biomolecular Informatics

Center for Molecular and Biomolecular Informatics

The Center for Molecular and Biomolecular Informatics (CMBI) does research and education, and provides services in bioinformatics and cheminformatics.


Staff & scientists at the CMBI


Contact Head of the CMBI

Peter-Bram 't Hoen
head of department

+31 (0)24 361 93 90
contact


Mission & vision

Our mission

Our mission is to add value to personal health data by their translation into integrative knowledge and actionable information.

Our vision 

  • CMBI develops bioinformatics approaches that contribute to the understanding of disease mechanisms, personalized therapies and interventions, and a learning health care system
  • CMBI is committed to the reusability of their data, tools, and services
  • CMBI provides  bioinformatics researchers in Radboudumc with a platform for exchange of knowledge and expertise
  • CMBI contributes to the education of BMW, MLW, and MMD students so that they can apply and understand the principles behind (existing) bioinformatics tools

Radboudumc Technology Center Bioinformatics

The Bioinformatics technology center aims to raise and solve biological questions using the most recent computer technologies and big data solutions.

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Education

Our mission is to provide a basic understanding in Bioinformatic principles. Follow-up courses are available for those who want to gain greater insight in our field.

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Education

Researchers at the CMBI contribute to several courses at both the Faculty of Science and the Medical Faculty. We provide courses in Structural Bioinformatics, Comparative Genomics, Data Analysis, and programming courses such as Java. We specifically focus on the Molecular Life Science students, Biomedical Sciences students and participants in the master Molecular Mechanisms of Disease, although some of our courses can be chosen by Biology, Chemistry or Medical students as well. 

Our mission is to provide a basic understanding in Bioinformatic principles for bachelor students as this was shown to be beneficial for those who want to pursue a career in Life Sciences. Follow-up courses are available for those who want to gain greater insight in our field. 

For MLS/Biology students it is even possible to follow the B-track by choosing a combination of (master) Bioinformatics courses and internships at Bioinformatics departments. 

Our researchers also teach in special interest courses and summer schools here at the Radboudumc, the Radboud University and elsewhere.

 

For more information, you can contact dr. Hanka Venselaar, education coordinator at the CMBI.

 

 


Internships

The CMBI offers a wide range of possibilities for internships.

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Internships

Both bachelor and master students from studies such as Molecular Life Sciences, Biomedical Sciences, Chemistry and MMD are welcome. In general, we are flexible in terms of internship length, type of internship and type of research. 

Below you can find our internship projects:


  • Description

    The human protein usherin, encoded by the USH2A gene, is involved in hearing and vision as a member of the USH2 complex. This complex forms the stereociliary ankle link complex at the apical surface of the sensory cells of the inner ear, the cochlear hair cells, and is required for the proper formation of the developing hair bundles. In retina photoreceptors, the USH2 complex is present at the periciliary membrane and is thought to play a role in regulating intracellular protein transport.
     
    Mutations in USH2A either lead to Usher syndrome, a both genetically and clinically heterogeneous condition characterized by progressive vision loss as a consequence of retinitis pigmentosa combined with sensorineural congenital hearing impairment, or to non-syndromic retinitis pigmentosa. The hearing impairment can be partially compensated by fitting of hearing aids or cochlear implants. Although, for the loss of vision currently no treatment options exist.
     
    dr. Erwin van Wijk's group at the department of Otorhinolaryngology focuses on unraveling the pathogenic mechanisms underlying Usher syndrome and developing genetic therapies for this condition. One of their successful approaches consists of an RNA-based antisense oligonucleotide (AON) therapy which induces the in frame skipping of a mutated exon during the process of pre-mRNA splicing. The 3D-structure of the resulting protein indicates that a well-chosen exon-skip can result in a functional, albeit slightly shortened protein. The first AON for USH2A-associated disease is currently being evaluated in a phase 1/2 clinical trial.
     
    In this internship, you will be studying and identifying the requirements for a successful exon-skipping approach. You will take into account the available information on, amongst others,  protein type, domain content, 3D-structure, exon-boundaries, splice modulating factors, evolutionary conservation, and protein-protein interactions. The goal is to generate a bio-informatic pipeline which enables the prediction of successful targets for the development of exon-skipping therapies.


    Supervisors: Erwin van Wijk (Otorhinolaryngology) / Hanka Venselaar (CMBI)
    Proposed duration: 5 month or more
    Preferred background: BMW-master (course BMS39), MLS (courses MOL066)
    Requirements: Experience with 3D-visualisation software, genomic databases 

     

     


Bioinformatics Services

We maintain computational facilities, databases, and software packages in bioinformatics.

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Organisation


Our researchers CMBI

A list of researchers connected to this department.

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Research groups CMBI

Discover some of our research that is related to molecular and biomolecular informatics.

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Contact Business manager

Nicolai Giling
Business manager

+31 (0)24 3686538
contact

Contact Operational manager

Barbara van Kampen
Operational manager

+31 (0)24 361 93 90
contact

Getting there

Entrance: Radboud Institute for Molecular Life Sciences
Route: 260

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Getting there

Visiting address

Radboud Institute for Molecular Life Sciences
Geert Grooteplein 28
6525 GA Nijmegen

Directions

Enter building at: Radboud Institute for Molecular Life Sciences
Follow route 260

Research themes

Affiliated institutes

Radboud Institute for Health Sciences

This department is affiliated with RIHS. The research at this institute aims to improve clinical practice and public health. institute pages

Radboud Institute for Molecular Life Sciences

This department is affiliated with RIMLS. Their main aim is to achieve a greater understanding of the molecular mechanisms of disease. institute pages