Mass spectrometry Expertise and services

The Technology Center for Mass Spectrometry offers high-level expertise in bioanalytical mass spectrometry combined with in-depth knowledge on biomedical and clinical applications, embedded in a cutting-edge clinical and fundamental research environment.

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Mass spectrometry Expertise and services

Areas of expertise

  • Bioanalytical mass spectrometry
  • Biomarkers for clinical diagnostics

Services

  • Develop and apply methods to analyze proteins, glycans and metabolites aiming at the identification and validation of novel biomarkers for clinical diagnostics.
  • Aid in quantifying low molecular weight drugs and their metabolites in body fluids and tissues using mass spectrometry as core technology.

How can we help enhance your research?

dr. Jolein Gloerich
Technology center representative

+31 (0)24 361 63 97
contact

What is mass spectrometry?

Mass spectrometry is a powerful analytical technique that measures the mass of ionized molecules for identification and quantization in simple and complex mixtures.

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What is mass spectrometry?

Mass spectrometry is a powerful analytical technique that measures the mass of ionized molecules for identification and quantization in simple and complex mixtures.

A mass spectrometer generates multiple ions from the sample, it then separates them according to their mass-to-charge ratio (m/z) and then records the relative abundance of each ion type. In biomedical applications, mass spectrometry is often combined with separation techniques such as liquid or gas chromatography and applied to study small molecules such as metabolites and drugs, but also larger biomolecules such as proteins and glycans.


National and international network

The core team of our RTC MS (the Translational Metabolic Laboratory) is also linked to:

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National and international network

X-omics

The core team of the RTC MS at the Translational Metabolic Laboratory is also part of the Netherlands X-omics initiative, which is part of the National Radmap for Large-Scale Research Infrastructures. The X-omics helpdesk is dedicated for questions on combining different omics approaches. More information can be found on the X-omics website.

EATRIS

Also, the core team of the RTC MS at the Translational Metabolic Laboratory is linked to the European Infrastructure for Translational Medicine (EATRIS) and participates in the Eatris Plus Fagship project in personalized medicine funded by H2020. More information can be foudn on the EATRIS website.

Fields within mass spectrometry


Bioanalysis of pharmaceuticals and toxicants

We have ample experience in the bioanalysis of small molecule pharmaceuticals and toxicants for measurement of these molecules in a wide variety of biological matrices for experimental, translational and clinical pharmacological, as well as toxicological research questions. read more

Exposomics

We offer our expertise and services to resolve your questions regarding the exposome. The exposome encompasses the totality of human environmental exposures from conception onwards. It complements the genome. Exposomics refers to the systematic determination of environmental exposures. read more

Hepcidin Analysis

We offer high quality mass-spectrometry based analysis of the iron regulatory hormone hepcidin to serve the scientific, medical and pharmaceutical communities. read more

Metabolomics

We have experience in metabolite measurements and hosts state-of-the-art equipment for targeted and untargeted metabolite analyses. read more

Glycomics

We provide diagnostics for glycosylation and lysosomal disorders and aim to improve our methods using new state-of-the-art mass spectrometry.

Proteomics

We focus on mass spectrometry-based protein analyses and have proteomics expertise in a wide range of biological and analytical applications. read more

Our experts