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Mass spectrometry Expertise and services
The Technology Center for Mass Spectrometry offers high-level expertise in bioanalytical mass spectrometry combined with in-depth knowledge on biomedical and clinical applications, embedded in a cutting-edge clinical and fundamental research environment. read moreMass spectrometry Expertise and services
Areas of expertise
- Bioanalytical mass spectrometry
- Biomarkers for clinical diagnostics
Services
- Develop and apply methods to analyze proteins, glycans and metabolites aiming at the identification and validation of novel biomarkers for clinical diagnostics.
- Aid in quantifying low molecular weight drugs and their metabolites in body fluids and tissues using mass spectrometry as core technology.
What is mass spectrometry?
Mass spectrometry is a powerful analytical technique that measures the mass of ionized molecules for identification and quantization in simple and complex mixtures. read moreWhat is mass spectrometry?
Mass spectrometry is a powerful analytical technique that measures the mass of ionized molecules for identification and quantization in simple and complex mixtures.
A mass spectrometer generates multiple ions from the sample, it then separates them according to their mass-to-charge ratio (m/z) and then records the relative abundance of each ion type. In biomedical applications, mass spectrometry is often combined with separation techniques such as liquid or gas chromatography and applied to study small molecules such as metabolites and drugs, but also larger biomolecules such as proteins and glycans.
National and international network
The core team of our RTC MS (the Translational Metabolic Laboratory) is also linked to: read moreNational and international network
X-omics
The core team of the RTC MS at the Translational Metabolic Laboratory is also part of the Netherlands X-omics initiative, which is part of the National Radmap for Large-Scale Research Infrastructures. The X-omics helpdesk is dedicated for questions on combining different omics approaches. More information can be found on the X-omics website.
EATRIS
Also, the core team of the RTC MS at the Translational Metabolic Laboratory is linked to the European Infrastructure for Translational Medicine (EATRIS) and participates in the Eatris Plus Fagship project in personalized medicine funded by H2020. More information can be foudn on the EATRIS website.
Fields within mass spectrometry
Bioanalysis of pharmaceuticals and toxicants
We have ample experience in the bioanalysis of small molecule pharmaceuticals and toxicants for measurement of these molecules in a wide variety of biological matrices for experimental, translational and clinical pharmacological, as well as toxicological research questions. read moreExposomics
We offer our expertise and services to resolve your questions regarding the exposome. The exposome encompasses the totality of human environmental exposures from conception onwards. It complements the genome. Exposomics refers to the systematic determination of environmental exposures. read moreHepcidin Analysis
We offer high quality mass-spectrometry based analysis of the iron regulatory hormone hepcidin to serve the scientific, medical and pharmaceutical communities. read more
