Research Research groups Regenerative biomaterials

About this research group

The Regenerative Biomaterials research group at Radboudumc creates novel biomaterial-based therapies for regeneration of hard tissues. Overall, our main aim is to decipher which physicochemical properties of biomaterials are able to trigger the natural self-healing capacity of hard tissues.

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About this research group

The Regenerative Biomaterials research group at Radboudumc creates novel biomaterial-based therapies for regeneration of hard tissues. Overall, our main aim is to decipher which physicochemical properties of biomaterials are able to trigger the natural self-healing capacity of hard tissues. Our design philosophy is highly translational and aimed at bridging the gap between basic and clinical sciences. To this end, experimental data are translated to pre-clinical (animal) and clinical (human) studies to benefit patients.

We strive to overcome major shortcomings of conventional biomaterials by smart design of biomaterials with improved biological, mechanical and handling performance. To this end, we synthesize a wide range of nano- and microstructured biomaterials including injectable, biodegradable and self-healing 3D hydrogels and cements, 2D barrier membranes and coatings, as well as organic or inorganic nanoparticles. These biomaterials are functionalized with various types of therapeutic biomolecules (e.g. antibacterial or anti-cancer drugs) and/or patient-derived cells (e.g. stem cells or immune cells) to tune their capacity to induce tissue regeneration for both healthy and diseased patients.


Research group leader

prof. dr. ir. Sander Leeuwenburgh

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Aims of this research group

  • designing novel biomaterial-based therapies with superior regenerative efficacy
  • deciphering which physicochemical properties of biomaterials trigger the natural self-healing capacity of hard tissues
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Aims of this research group

This research group aims:
  • to design novel biomaterial-based therapies with superior regenerative efficacy;
  • to decipher which physicochemical properties of biomaterials trigger the natural self-healing capacity of hard tissues;
  • to maximize the regenerative capacity of biomaterials by functionalization with cells and therapeutic biomolecules;
  • to develop predictive models for hard tissue regeneration.

Discoveries by this research group

  • fully resorbable bioceramic bone cements
  • self-healing biomaterials for hard tissue regeneration
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Discoveries by this research group

Some discoveries by this research group are:
  • fully resorbable bioceramic bone cements;
  • self-healing biomaterials for hard tissue regeneration;
  • superior biological and mechanical performance of nanostructured biomaterials;
  • osteoclast-induced bone regeneration.