About the position
- 36 hours per week
- Temporary
- 14 months
- Salary scale 10
- Fulltime: min € 3598 - max € 5669 gross per month
- Apply before 13 August 2025
Job description
Nephrogenic Diabetes Insipidus (NDI) is a rare renal disorder without a cure. In this project, we aim to establish a human organoid-based drug screening platform to identify personalized therapies that restore water transport in NDI patients. As a postdoctoral researcher, you will play an... read moreJob description
Nephrogenic Diabetes Insipidus (NDI) is a rare renal disorder without a cure. In this project, we aim to establish a human organoid-based drug screening platform to identify personalized therapies that restore water transport in NDI patients. As a postdoctoral researcher, you will play an important role in developing and applying human (patient-derived) tubuloid NDI models. Are you our new colleague? This is your opportunity to make a tangible impact on therapy development for a rare disease!
Our group recently established tubuloids as models that are capable of vasopressin receptor 2 (V2R)-dependent water transport. To follow-up on these promising results, these models will be used to identify novel therapeutic targets and test a library of pharmacological chaperones for their ability to restore receptor trafficking, V2R-stimulated cAMP signaling, and water transport. Your work will include advanced molecular and cell culture techniques, multi-omics appraoches (including single cell RNAseq and proteomics) and live-cell imaging, enabled by state-of-the-art facilities available at Radboudumc.
In this project, you will:
- Generate and maintain isogenic iPSC lines with AVPR2 and AQP2 mutations.
- Integrate and utilize CFP-Epac-YFP constructs to monitor dynamic cAMP signaling in real-time.
- Generate NDI disease model iPSCs-derived tubuloids.
- Perform water transport assays and microscopty to assess water transport and signaling.
- Screen molecular chaperones for their capacity to rescue the NDI phenotype using high-throughput microscopy.
- Analyze imaging and functional data and contribute to method optimization.
- Potentially also test drug candidates on patient derived tubuloids
Place of work
This project is embedded in the Molecular Physiology group at the Department of Medical Biosciences and supervised by Prof. Joost Hoenderop. The department provides an international and stimulating working environment. The Molecular Physiology group consists of around 20 researchers including PhD...
read morePlace of work
This project is embedded in the Molecular Physiology group at the Department of Medical Biosciences and supervised by Prof. Joost Hoenderop. The department provides an international and stimulating working environment. The Molecular Physiology group consists of around 20 researchers including PhD candidates, postdocs and technical staff. The wider department consists of over 100 researchers working across various fields including physiology, molecular biology and imaging. Our research focuses on the molecular mechanisms of kidney function and tubulopathies, using advanced in vitro models to identify therapeutic targets. The lab offers a collaborative and cutting-edge research environment and is well integrated into national and international research consortia.
Our labs are housed in the modern Radboudumc Research Tower, featuring state-of-the-art facilities, shared open workspaces, and specialized labs for e.g. imaging and cell culture. The team enjoys a friendly, supportive atmosphere with regular science meetings, coffee- and lunch breaks. And occational treats to celebrate birthdays or scientific successes are not out of the ordinary! We offer an ideal setting to develop your skills, grow your network, and contribute to meaningful research.
Radboudumc
Welcome to Radboud university medical center (Radboudumc), where our research groups strive for innovative solutions that make impact on health and healthcare. We challenge the status quo to overcome current and future health challenges. Our goal is to shape the future of healthcare for generations to come. Our focus is on prevention, sustainability, and meaningful care, which we achieve through our in-depth understanding of disease mechanisms, clinical science, public health research, medical technology and data science. Our approach is centered on breakthroughs that can truly enhance personalized healthcare and public health.
At Radboudumc, a comprehensive range of research programs provide the compass for our research efforts. Each program has a clear goal, where collaboration within and outside our organization is highly valued. We integrate care, education and research in partnership with our patients to ensure that our research programs have significant impact on health and healthcare. We invite you to join us in our mission to create a healthy future for all.
Profile
You have a PhD in Biomedical Sciences, Molecular Cell Biology, Stem Cell Biology, Physiology, or a related discipline. You have hands-on experience with stem cell culture, organoid models, or kidney physiology is a strong plus.
Furthermore:
- Familiarity with fluorescent microscopy, or high-content screening is favourable.
- Proven ability to work independently and collaboratively in a multidisciplinary team.
- Excellent communication skills in English (spoken and written).
- Enthusiasm for translational research with a clear patient benefit.
Let's meet


Employment conditions
At Radboud university medical center, you build on your future. We are committed to providing the best care, education, and research. And we are true to our word, because we help you develop and seize opportunities and give you the room to grow. As an employer, we believe that employees should...
read moreEmployment conditions
At Radboud university medical center, you build on your future. We are committed to providing the best care, education, and research. And we are true to our word, because we help you develop and seize opportunities and give you the room to grow. As an employer, we believe that employees should feel vital and happy at work in all stages of life. We are also committed to creating a healthy and safe working environment. Our employment conditions contribute to that. What we offer:
- A gross monthly salary between € 3.598 and € 5.669 (scale 10) for full-time employment (36 hours per week). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, and, depending on the position, an allowance of 47% to 72% for working irregular hours.
- 176 vacation hours per year based on a 36-hour working week.
And there is more..
- An Employment Conditions Selection Model, allowing you to use part of your employment conditions to your choosing. For example, you can use your gross salary to purchase additional vacation hours or hours for providing informal caregiving. Or, for example, you can use your gross end-of-year bonus to purchase a bicycle, so you pay less tax.
- Plenty of opportunities for personal development. You can take a variety of courses in our online learning environment.
- Your well-being and vitality are a priority. For example:
- Save time for work-life balance leave.
- You can enjoy unlimited access to a variety of activities five days a month and take advantage of all the facilities at Radboud Sport & Culture for only €27.05 per month (instead of €41)
- Healthy Professionals program to help you manage your energy.
- Company Support Team and a personal coach if you are going through a life-changing event.
- Financially beneficial working less through a Generation Scheme as you approach state pension age.
- Support in achieving a good work-life balance at every stage of your life. Examples:
- Advice and courses on, for example, 'Millennial dilemmas' and 'Your Career After 57'.
- Activities at our own mindfulness center.
- Informal caregiving consultations if you have questions about juggling work and caregiving responsibilities at home.
- In addition to statutory pregnancy and maternity leave, Radboud university medical center offers 26 weeks of parental leave, nine of which are paid. In addition, as a partner you can take a maximum of five weeks of supplementary partner leave. During supplementary partner leave and parental leave, we supplement the UWV benefit up to 100% of your salary.
- Pension accrual at the ABP Pension Fund. Radboud university medical center pays 70% of the pension premium.
- Discounts on supplementary packages of two group health insurances and ten other types of insurance, from home insurance to legal assistance.
- An allowance for your commuting costs of € 0.18 per km up to a maximum of 40 km one way. If you use public transport to commute, we will fully reimburse the public transport costs (2nd class). If you regularly work from home, you will receive a working from home allowance of € 2.40 per day.



Application procedure
Are you ready to think further for our patients and our care? We would like to receive your application before 13 August 2025. We will then contact you shortly. An assessment may be part of this application procedure.
read moreApplication procedure
Are you ready to think further for our patients and our care? We would like to receive your application before 13 August 2025. We will then contact you shortly. An assessment may be part of this application procedure.
Good to know
- This position requires a Certificate of Conduct (VOG).
- You can find more information about our application procedure and frequently asked questions on our website.
- Will you be our new colleague? Then you will be given the time and space to get to know your role, your workplace, and your colleagues. An induction day for all new colleagues is an integral part of your onboarding program.
We are recruiting for this position ourselves. Unsolicited marketing is not appreciated, but do feel free to share the vacancy in your network!

Contact
Any questions? Or wondering what it is like to work at Radboudumc? Then email to prof. dr. Joost Hoenderop, full professor / research group leader. Use the Apply button to submit your application. read moreContact
Any questions? Or wondering what it is like to work at Radboudumc? Then email to prof. dr. Joost Hoenderop, full professor / research group leader. Use the Apply button to submit your application.
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