Cerebral circulation and cognition in aging humans
Jurgen Claassen's research group uses various techniques to measure cerebral perfusion, cerebral autoregulation and cognitive activation. These physiological mechanisms play an important role in Alzheimer’s disease, hypertension, and cognitive aging.
Cerebral circulation and cognition: Translational neurosciene
Amanda Kiliaan’s research group uses a multidisciplinary approach to study the link between (cerebro)vascular disorders and neurodegeneration. Within this group, neuroimaging is an important tool to study aspects of cerebral hemodynamics (e.g. cerebral blood flow/volume, vasoreactivity).
Clinical neuroscience in psychiatry
Indira Tendolkar's group focuses the intersection between clinical psychiatry and cognitive neuroscience with a focus on declarative memory. We investigate the adapatation of emotional and neutral memory processes depending on genetic and environmental variablity including somatic challenges.
Cognitive and affective neuroscience
Erno Hermans's research group investigates how neurochemicals affect diverse cognitive functions, such as vigilance, executive function, and memory. Moreover, they study how stressful experiences alter the intrinsic neural dynamics in the brain and how such processes contribute to memory.
Establishing physiological biomarkers of perioperative stress
Jurgen Fütterer's group conducts imaging and cognitive research at the intersection between clinical psychiatry and cognitive neuroscience with a focus forms of declarative memory that also play a role in development and maintenance of stress-related mental disorders.
Genetics of multifactorial eye diseases
Anneke den Hollander's research group aims to understand the molecular disease mechanisms of common forms of vision loss, to determine which molecular factors can influence response to therapy, and to stratify patients for the most optimal therapy based on their molecular profile.
Macular degeneration and ophthalmogenetics
Carel Hoyng's research group specializes in studying the genetics of retinal disorders. The two main research activities are age-related macular degeneration , a research program which has been started to develop better visual rehabilitation, and Ophthalmogenetics.
Neurological movement disorders
Bas Bloem's first research line aims at studying human motor control in health and disease, in particular patients with neurological movement disorders. A second main interest is in health care innovation, aiming to develop and scientifically evaluate patient-centred collaborative care.
Translational genomics of neurodevelopmental disorders
Annette Schenck's research focuses on dissecting molecular networks and mechanisms underlying human brain function and disease. In order to be able to investigate the large number of genes, we use a powerful genetic model organism, the fruitfly Drosophila melanogaster.
Usher syndrome: Genetics and functional genomics
Hannie Kremer's group aims to identify genetic defects that underlie hereditary hearing impairment and to unravel the molecular pathogenesis. Identification of deafness genes provides knowledge on inner ear function. Furthermore, it will provide handles for the development of future therapy.