7 April 2017

As the incidence of esophageal adenocarcinoma (EAC) and its precursor Barrett’s esophagus (BE) has increased dramatically during the last decades, strategies to counter this need to be explored.

I, Yonne Peters, am a PhD student at the department of Gastroenterology and Hepatology under supervison of prof. dr. P.D. Siersema. I will especially focus on the role of screening and surveillance in BE patients.
 
However, the role of screening and surveillance in patients with Barrett's oesophagus remains controversial. The use of novel endoscopic techniques and biomarkers combined with better identification of high-risk groups could improve the effectiveness of screening and surveillance in BE patients. Besides, combined with effective endoscopic treatment for dysplasia and early staged cancer, it could help reverse the increased incidence of EAC and reduce its mortality.
 
In order to achieve this, we aim to improve screening by characterizing a well-defined high risk population and to assess the population-at-risk in the Netherlands. Furthermore, we will test an electronic nose device, as a new non-invasive and less costly screening tool for BE. Second, surveillance strategies for BE and their effect on malignant progression will be analyzed, in order to optimize surveillance and follow-up strategies. At last, we will study the possibility of probiotics to reduce the inflammation and thereby the risk of neoplastic progression in BE by influencing the esophageal microbiota.

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