6 June 2019

In Nature Reviews Disease Primers Yonne Peters and Ali Al-Kaabi provided a global overview of Barrett oesophagus and outlined key open research questions. This primer covered epidemiology, disease mechanism, diagnose, screening, prevention, management, and quality of life.

In Nature Reviews Disease Primers Yonne Peters and Ali Al-Kaabi provided an up-to-date overview of Barrett oesophagus, a precursor of oesophageal adenocarcinoma. We discussed the epidemiology and pathophysiology, the criteria for the diagnosis of Barrett’s and explored developments in screening and surveillance. In addition, we reviewed the management, including endoscopic eradication strategies, and the effect of the condition on the quality of life of patients. The article gives a global perspective for the benefit of biomedical scientists, putting current clinical and translational challenges into context.

Abstract
Barrett oesophagus (BE), the only known histological precursor of oesophageal adenocarcinoma (EAC), is a condition in which the squamous epithelium of the oesophagus is replaced by columnar epithelium as an adaptive response to gastro-oesophageal reflux. EAC has one of the fastest rising incidences of cancers in Western countries and has a dismal prognosis. BE is usually detected during endoscopic examination, and diagnosis is confirmed by the histological presence of intestinal metaplasia. Advances in genomics and transcriptomics have improved our understanding of the pathogenesis and malignant progression of intestinal metaplasia. As the majority of EAC cases are diagnosed in individuals without a known history of BE, screening for BE could potentially decrease disease-related mortality. Owing to the pre-malignant nature of BE, endoscopic surveillance of patients with BE is imperative for early detection and treatment of dysplasia to prevent further progression to invasive EAC. Developments in endoscopic therapy have resulted in a major shift in the treatment of patients with BE who have dysplasia or early EAC, from surgical resection to endoscopic resection and ablation. In addition to symptom control by optimization of lifestyle and pharmacological therapy with proton pump inhibitors, chemopreventive strategies based on NSAIDs and statins are currently being investigated for BE management.

Publication
Barrett oesophagus.
Peters Y, Al-Kaabi A, Shaheen NJ, Chak A, Blum A, Souza RF, Di Pietro M, Iyer PG, Pech O, Fitzgerald RC, Siersema PD.

Yonne Peters and Ali Al-Kaabi are members of theme Tumors of digestive tract.

Related news items


Electronic nose smells precursor of oesophageal cancer

5 March 2020

A portable electronic nose can effectively detect precursors of oesophageal cancer, reported by RIHS researchers Yonne Peters and Peter Siersema in the medical science journal GUT. This was demonstrated in an initial study involving more than four hundred patients.

read more

Mohrmann Stipend for Bakker and Peters

12 December 2019

Tuesday 10 December, Esmée Bakker and Yonne Peters were awarded a Christine Mohrmann stipend. The grant – 5000 euros each – gives them an opportunity to spend time at another university, preferably one abroad.

read more

Electronic nose detects bacterium that can cause stomach cancer

10 September 2019

OP Oost promotes innovative cooperation between companies and research institutions.

read more

How to approach a patient with refractory or recurrent benign esophageal stricture

31 January 2019

In Gastroenterology Peter Siersema described the currently used treatment modalities for complex esophageal strictures, based on underlying cause and symptom duration, but also focusing on future treatment perspectives.

read more

Low risk of progression in persistent non-dysplastic Barrett’s esophagus

19 September 2018

In Clinical Gastroenterology and Hepatology Peter Siersema and Yonne Peters showed that patients with stable persistence of non-dysplastic Barrett’s esophagus have a low risk of malignant progression and may not benefit from routine endoscopic surveillance.

read more

Ayla Turan jury and audience award winner Radboud Talks 2018

18 April 2018

Watch Ayla's pitch about the prevention of bleedings after the removal of polyps in the intestines.

read more