6 June 2019

In Nature Reviews Disease Primers Yonne Peters and Ali Al-Kaabi provided a global overview of Barrett oesophagus and outlined key open research questions. This primer covered epidemiology, disease mechanism, diagnose, screening, prevention, management, and quality of life.

In Nature Reviews Disease Primers Yonne Peters and Ali Al-Kaabi provided an up-to-date overview of Barrett oesophagus, a precursor of oesophageal adenocarcinoma. We discussed the epidemiology and pathophysiology, the criteria for the diagnosis of Barrett’s and explored developments in screening and surveillance. In addition, we reviewed the management, including endoscopic eradication strategies, and the effect of the condition on the quality of life of patients. The article gives a global perspective for the benefit of biomedical scientists, putting current clinical and translational challenges into context.

Abstract
Barrett oesophagus (BE), the only known histological precursor of oesophageal adenocarcinoma (EAC), is a condition in which the squamous epithelium of the oesophagus is replaced by columnar epithelium as an adaptive response to gastro-oesophageal reflux. EAC has one of the fastest rising incidences of cancers in Western countries and has a dismal prognosis. BE is usually detected during endoscopic examination, and diagnosis is confirmed by the histological presence of intestinal metaplasia. Advances in genomics and transcriptomics have improved our understanding of the pathogenesis and malignant progression of intestinal metaplasia. As the majority of EAC cases are diagnosed in individuals without a known history of BE, screening for BE could potentially decrease disease-related mortality. Owing to the pre-malignant nature of BE, endoscopic surveillance of patients with BE is imperative for early detection and treatment of dysplasia to prevent further progression to invasive EAC. Developments in endoscopic therapy have resulted in a major shift in the treatment of patients with BE who have dysplasia or early EAC, from surgical resection to endoscopic resection and ablation. In addition to symptom control by optimization of lifestyle and pharmacological therapy with proton pump inhibitors, chemopreventive strategies based on NSAIDs and statins are currently being investigated for BE management.

Publication
Barrett oesophagus.
Peters Y, Al-Kaabi A, Shaheen NJ, Chak A, Blum A, Souza RF, Di Pietro M, Iyer PG, Pech O, Fitzgerald RC, Siersema PD.

Yonne Peters and Ali Al-Kaabi are members of theme Tumors of digestive tract.

Related news items


Social media posts on medication use during pregnancy often incorrect

23 August 2019

Dutch social media regularly post about the safety of medicines for pregnant women. Many pregnant women use these posts as a source of information. A new analysis shows, however, that information found on social media about the risk of medication use often does not correspond with guidelines.

read more

Hans van Bokhoven newly elected in Academia Europaea

22 August 2019

The Academia Europaea is a functioning European Academy of Humanities, Letters and Sciences, composed of individual members.

read more

Drug-induced interstitial lung disease in advanced breast cancer patients receiving everolimus

22 August 2019

In Targeted Oncology, Annelieke Willemsen, Carla van Herpen and colleagues, showed that pulmonary function test with diffusion capacity of the lungs for carbon monoxide and serum biomarkers can be of aid to differentiate everolimus-related interstitial lung disease from other respiratory problems.

read more

Publication in PNAS on dissecting EEC syndrome using single-cell RNA-seq

22 August 2019

PhD candidates Eduardo Soares and Quan Xu in Jo Huiqing Zhou’s group in Molecular Developmental Biology, theme Reconstruction and regenerative medicine, have published a paper in PNAS on the disease mechanism of EEC syndrome using single-cell RNA-seq technology and patient-derived iPSCs.

read more

Patient trust and participation in cell biological research

21 August 2019

Alessandra Cambi and Gert Olthuis, discuss key ethical issues inherent in the development and the value of building trust and trustworthiness.

read more

NWO grant for a tissue-generating patch to close diaphragmatic defects

21 August 2019

Willeke Daamen and Toin van Kuppevelt, theme Reconstructive and regenerative medicine, were recently awarded a 690 k€ grant by NWO, domain Applied & Engineering Sciences, for the development of advanced patches for closure of diaphragmatic defects in children with congenital diaphragmatic hernia.

read more