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31 May 2017
Vidi for Christian Gilissen - Theme Neurodevelopmental disorders
Thanks to new DNA reading techniques in the recent years, it has become much simpler to track changes in DNA. Still, it remains very difficult to see which variants of DNA cause a genetic condition. That is why not all patients can receive a genetic diagnosis. Even if we can give patients a genetic diagnosis, we often understand little of the underlying biological mechanisms that cause the disease, and which would provide us a foothold to treatment and therapy.
Dr. Gilissen will combine these genetic data with undirected metabolite measurements in patients. In order to do so, he will develop new techniques to to analyze metabolite data and to combine them with DNA data: a functional genomics approach. This way, he aims to forst find new causes for genetic conditions, second to obtain insights into the biological processes that underly intellectual disability, and third to develop new methods to understand the consequences of non-coding mutations in DNA.
> see the personal page of Christian Gilissen for more information about his research
Combining metabolites and genetics to understand disease
Vidi for Christian Gilissen - Theme Neurodevelopmental disorders
Thanks to new DNA reading techniques in the recent years, it has become much simpler to track changes in DNA. Still, it remains very difficult to see which variants of DNA cause a genetic condition. That is why not all patients can receive a genetic diagnosis. Even if we can give patients a genetic diagnosis, we often understand little of the underlying biological mechanisms that cause the disease, and which would provide us a foothold to treatment and therapy.
Dr. Gilissen will combine these genetic data with undirected metabolite measurements in patients. In order to do so, he will develop new techniques to to analyze metabolite data and to combine them with DNA data: a functional genomics approach. This way, he aims to forst find new causes for genetic conditions, second to obtain insights into the biological processes that underly intellectual disability, and third to develop new methods to understand the consequences of non-coding mutations in DNA.
> see the personal page of Christian Gilissen for more information about his research
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