Researchers of the Radboudumc and colleagues, have successfully developed enzyme-loaded polymersomal nanoreactors capable of undergoing cellular integration in a controlled fashion and, subsequently, function as synthetic organelles. They published their findings in ACS Central Science.Pubication in ACS Central Science: link.
For the first time, patient-derived complex I-deficient primary skin fibroblasts are effectively protected against the toxicity of exogenous hydrogen peroxide by the action of internalized catalase-loaded nanoreactors, showcasing this system in a therapeutically relevant context.
The work was performed by PhD candidate Lisanne van Oppen and co-workers in the laboratories of Biochemistry and Pediatrics, theme Mitochondrial diseases, of the Radboudumc and assistant professor Loai Abdelmohsen and co-workers in the research group of Bio-Organic Chemistry at the Eindhoven University of Technology.
Related news items
4,8 million euros for prevention of tuberculosis among people with diabetes in Africa16 July 2019
Reinout van Crevel and Lindsey te Brake have received European funding of 4.8 million euros to lead an international consortium to screen thousands of people with diabetes in Uganda and Tanzania for TB, and investigate the effect and costs of 3 months preventive treatment for TB.read more
Handbook of biomarkers and precision medicine a new publication by Alain van Gool12 July 2019
Alain van Gool published a new handbook on biomarkers and applications in (pre)clinical drug development for precision medicine.read more
The real impact of menstrual complaints on work and school productivity8 July 2019
Menstrual period symptoms may be linked to nearly nine days of lost productivity every year, through presenteeism, suggests the largest study of its kind, published in the journal BMJ Open. But the real impact on women and society is underestimated and poorly appreciated, say the researchers.read more
Successful Summer School by CMBI, TML and Human Genetics8 July 2019
CMBI, TML and Human Genetics organized a successful Summer School on 'Integrative X-omics Analyses Empowering Personalized Healthcare'.read more