CD44-positive proliferating glomerular cells, most likely parietal epithelial cells, are essential in the pathogenesis of scarring glomerular disease.
In a recent publication in Kidney International a multidisciplinary team integrated by Jennifer Eymael and Bart Smeets, Dept. of Pathology and Johan van der Vlag, Dept. of Nephrology, theme Renal disorders, and collaborators from the Academic Medical Center, Amsterdam and the RWTH University of Aachen, Germany, has established novel molecular insights for understanding the role of parietal epithelial cells in the development of the typical glomerular lesions of crescentic glomerulonephritis and of glomerulosclerosis.
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